• Basic Info
• Top Questions
• Clinical Info
• Interactions

The pain-relieving effects of any narcotic pain medications you use will be reversed if you use them during your treatment with naloxone. Withdrawal symptoms could also occur, such as body aches, diarrhea, increased heart rate, fever, sweating, nausea or vomiting, irritability, trembling, weakness, and increased blood pressure. Your doctor may want to observe you after using naloxone to watch for side effects.

Before using naloxone, tell your doctor if you use any of the following drugs:

• buprenorphine (Buprenex, Subutex);

• butorphanol (Stadol);

• codeine (Tylenol with codeine);

• hydrocodone (Lortab, Vicodin);

• dezocine (Dalgan);

• hydromorphone (Dilaudid);

• levorphanol (Levo-Dromoran);

• meperidine (Demerol);

• methadone (Dolophine, Methadose);

• morphine (Kadian, MS Contin, Roxanol);

• nalbuphine (Nubain);

• nalmefene (Revex);

• naltrexone (ReVia);

• oxycodone (OxyContin, Roxicodone, Percocet);

• oxymorphone (Numorphan); or

• propoxyphene (Darvon, Darvocet).

This list is not complete and there may be other drugs that can interact with naloxone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naloxone and call your doctor at once if you have any of these serious side effects:

• chest pain or fast or irregular heartbeats;

• feeling light-headed, fainting;

• seizure (convulsions); or

• difficulty breathing.

Less serious side effects may include:

• dizzines, weakness, tired feeling;

• nausea, vomiting, or diarrhea;

• feeling nervous, restless, or excited;

• sweating;

• runny nose; or

• trembling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.