• Basic Info
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• Interactions

Do not take mesoridazine with other drugs that can affect heartbeat rhythms such as quinidine (Cardioquin, Quinaglute, Quinidex, others), procainamide (Procan, Procanbid, Pronestyl), disopyramide (Norpace), and others. Taken with any of these drugs, mesoridazine (Serentil) may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with mesoridazine and cause heart problems. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medications.

Mesoridazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if mesoridazine is taken with alcohol or any of these medications. Talk to your doctor before taking mesoridazine in combination with alcohol or any other prescription or over-the-counter medicines.

Drugs other than those listed here may also interact with mesoridazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking mesoridazine and seek emergency medical treatment:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs;

• fever;

• muscle rigidity;

• muscle spasms of the face or neck;

• sweating;

• irregular pulse;

• fast or irregular heartbeats.

• severe restlessness or tremor;

• severe drowsiness;

• blurred vision;

• dizziness or fainting; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take mesoridazine and talk to your doctor if you experience:

• dry mouth or stuffy nose;

• constipation;

• mild restlessness, drowsiness, or tremor;

• difficult urination or dark urine;

• decreased sex drive;

• increased appetite; or

• menstrual irregularities or swollen breasts.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.