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• Interactions

Many drugs can interact with itraconazole. Below is just a partial list. Tell your doctor if you are using:

• a blood thinner such as warfarin (Coumadin);

• cancer medications;

• cholesterol medications such as atorvastatin (Lipitor);

• cyclosporine (Gengraf, Sandimmune, Neoral);

• diabetes medication you take by mouth;

• digoxin (digitalis, Lanoxin);

• disopyramide (Norpace);

• fentanyl (Actiq, Duragesic);

• isoniazid (for treating tuberculosis);

• rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater, Rifamate), or rifapentine (Priftin);

• sirolimus (Rapamune) or tacrolimus (Prograf);

• an antibiotic such as clarithromycin (Biaxin), clotrimazole (Mycelex Troche), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), ketoconazole (Nizoral), telithromycin (Ketek), troleandomycin (Tao), or voriconazole (Vfend);

• an antidepressant such as nefazodone, paroxetine (Paxil), or sertraline (Zoloft);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);

• heart or blood pressure medications such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others;

• HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase, Fortovase), or ritonavir (Norvir);

• a sedative such as alprazolam (Xanax), diazepam (Valium); or

• seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and there are many other medicines that can interact with itraconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• fever;

• feeling short of breath, even with mild exertion;

• swelling, rapid weight gain;

• problems with hearing;

• numbness or tingly feeling;

• pain or burning when you urinate; or

• nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• diarrhea, constipation, mild stomach pain;

• mild itching or skin rash;

• headache, dizziness; or

• runny nose or other cold symptoms.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.