• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before using hydrocortisone rectal, tell your doctor if you also use insulin or other diabetes medications you take by mouth.

There may be other drugs that can interact with hydrocortisone rectal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• feeling short of breath, even with mild exertion;

• swelling of your ankles or feet;

• muscle weakness;

• rapid weight gain, especially in your face and midsection;

• severe rectal pain or burning;

• bleeding from your rectum;

• severe stomach pain;

• sudden and severe headache or pain behind your eyes; or

• seizure (convulsions).

Less serious side effects may include:

• mild rectal pain or burning;

• acne;

• changes in your menstrual periods;

• increased sweating; or

• increased facial or body hair growth.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.