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There may be other drugs that can affect gemcitabine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• pale skin, easy bruising or bleeding, unusual weakness;

• urinating less than usual or not at all;

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• fever, chills, body aches, flu symptoms;

• white patches or sores inside your mouth or on your lips;

• pain, swelling, or skin changes where the needle was placed;

• hearing problems;

• blood in your urine; or

• breathing problems.

Less serious side effects may be more likely to occur, such as:

• mild nausea, vomiting, upset stomach;

• diarrhea or constipation;

• swelling in your hands, ankles, or feet;

• skin rash;

• numbness or tingly feeling;

• drowsiness; or

• hair loss.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.