• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking fluconazole, tell your doctor if you are using any of the following drugs:

• astemizole (Hismanal).

• a blood thinner such as warfarin (Coumadin);

• cyclosporine (Gengraf, Sandimmune, Neoral);

• an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others;

• rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane);

• a sedative such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), or midazolam (Versed);

• seizure medication such as phenytoin (Dilantin) or valproic acid (Depakene);

• tacrolimus ((Prograf); or

• theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others).

This list is not complete and there may be other drugs that can interact with fluconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• fever, chills, body aches, flu symptoms;

• severe blistering, peeling, and red skin rash;

• easy bruising or bleeding, unusual weakness; or

• seizure (convulsions).

Less serious side effects may include:

• mild nausea, vomiting, diarrhea, or upset stomach;

• headache;

• dizziness;

• unusual or unpleasant taste in your mouth; or

• skin rash or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.