The following drugs can interact with epinephrine injection. Tell your doctor if you are using any of these:
digoxin (digitalis, Lanoxin, Lanoxicaps);
quinidine (Cardioquin, Quinaglute, Quinidex);
a tricyclic antidepressant such as amitriptyline (Elavil, Endep), nortriptyline (Pamelor), doxepin (Sinequan), imipramine (Tofranil), and others; or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
This list is not complete and there may be other drugs that can interact with epinephrine injection. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Before using epinephrine a second time, tell your doctor if your first injection caused a serious side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
fast or uneven heat rate;
sweating;
nausea and vomiting;
pale skin;
dizziness;
weakness or muscle tremors;
headache; or
feeling nervous or anxious.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
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