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Cold or allergy medicine, narcotic pain medicine, other sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by doxylamine. Tell your doctor if you need to use any of these other medicines while you are taking doxylamine.

Before taking this medication, tell your doctor if you are using any of the following drugs:

• a diuretic (water pill);

• diphenhydramine (Benadryl) applied to the skin as a spray, cream, lotion, gel, or stick;

• bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);

• medication to treat irritable bowel syndrome;

• bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

• aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others); or

• other antihistamines, or medicine to treat motion sickness.

If you are using any of these drugs, you may not be able to use doxylamine, or you may need dosage adjustments or special tests during treatment.

This list is not complete and there may be other drugs that can interact with doxylamine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heartbeat;

• confusion, hallucinations, unusual thoughts or behavior;

• severe dizziness, anxiety, restless feeling, or nervousness;

• urinating less than usual or not at all;

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

Keep using the medication and talk with your doctor if you have any of these less serious side effects:

• blurred vision;

• dry mouth;

• nausea, stomach pain, constipation;

• dizziness, drowsiness;

• problems with memory or concentration;

• ringing in your ears;

• restless or excitability (especially in children);