Print
EmailGeneric Name: docetaxel
FDA Alerts-
-
Treatment-related Mortality
- Incidence of treatment-related mortality increased in patients with abnormal hepatic function, patients receiving higher doses, and patients with non-small cell lung carcinoma previously treated with platinum-based chemotherapy who received docetaxel monotherapy at a dose of 100 mg/m2. Approximately half of deaths reported in breast cancer patients occurred during the first cycle; most deaths were due to sepsis.
-
Hepatic Impairment
- Docetaxel should not be administered to patients with serum total bilirubin >ULN, or patients with serum AST and/or ALT >1.5 times ULN concurrent with alkaline phosphatase >2.5 times ULN. These patients are at increased risk for grade 4 neutropenia, febrile neutropenia, infections, severe thrombocytopenia, severe stomatitis, severe skin toxicity, and toxic death. Increased risk for grade 4 febrile neutropenia, but not toxic death, in patients with isolated elevations of AST or ALT >1.5 times ULN.
- Obtain and review bilirubin, AST, ALT, and alkaline phosphatase values prior to each cycle.
-
Hematologic Monitoring
- Docetaxel should not be administered to patients with neutrophil counts <1500/mm3.
- Monitor blood cell counts frequently.
-
Hypersensitivity
- Severe hypersensitivity reactions (hypotension and/or bronchospasm, generalized rash/erythema) reported in patients who received the recommended 3-day dexamethasone premedication. Hypersensitivity reactions requiring discontinuance reported in patients who did not receive dexamethasone premedication. Hypersensitivity reactions resolved following discontinuance of the infusion and appropriate treatment.
- Do not administer to patients with a history of severe hypersensitivity reactions to docetaxel or polysorbate 80.
-
Fluid Retention
- Severe fluid retention (poorly tolerated peripheral edema, generalized edema, pleural effusion requiring urgent drainage, dyspnea at rest, cardiac tamponade, pronounced abdominal distention, ascites) reported in patients despite receiving the 3-day dexamethasone premedication.
-
Experience of Supervising Clinician
- Administer only under the supervision of qualified clinicians experienced in the use of cytotoxic therapy. Adequate diagnostic and treatment facilities should be readily available to manage complications.
Drug Info Tools-
Healthline Part D Plan Selector
Medicare's drug plans are subsidized by the US federal government and offered through insurers.
- Basic Info
- Top Questions
- Clinical Info
- Interactions
Do not receive "live" vaccines during treatment with docetaxel. Administration of a live vaccine may be dangerous during treatment with docetaxel.
There are many other drugs that can interact with docetaxel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Some people receiving a docetaxel injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection.
Get emergency medical help if you have any of these
Call your doctor at once if you have any of these serious side effects:
-
easy bruising or bleeding, unusual weakness;
-
feeling like you might pass out;
-
fever, chills, body aches, flu symptoms;
-
severe diarrhea;
-
skin changes or bruising where the IV was placed;
-
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
feeling short of breath, even with mild exertion;
-
swelling of your ankles or feet, weight gain;
-
a red, blistering, peeling skin rash; or
-
numbness, burning, pain, or tingly feeling.
Less serious side effects may include:
-
feeling weak or tired;
-
white patches or sores inside your mouth or on your lips;
-
mild nausea, vomiting, diarrhea, constipation, or loss of appetite;
-
watery eyes;
-
changes in menstrual periods;
-
temporary hair loss; or
-
fingernail or toenail changes.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
 |
 |
Advertise | Terms of Use | Privacy Policy