• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• isoniazid (Nydrazid);

• a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);

• a benzodiazepine such as diazepam (Valium), alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), temazepam (Restoril), triazolam (Halcion), and others;

• a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;

• warfarin (Coumadin);

• metronidazole (Flagyl);

• theophylline (Theo-Dur);

• phenytoin (Dilantin);

• lithium (Lithobid, Eskalith, others).

Drugs other than those listed here may also interact with disulfiram. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.

Severe and sometimes fatal liver problems have occurred in patients taking disulfiram even without a prior history of liver problems.

If you experience any of the following serious side effects, stop taking disulfiram and seek emergency medical attention:

• an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives);

• seizures;

• extreme tiredness;

• dark urine;

• yellowing of the skin or eyes (jaundice);

• large appetite changes;

• weakness, dizziness or loss of coordination; or

• severe diarrhea or vomiting.

Other, less serious side effects may be more likely to occur. Continue to take disulfiram and talk to your doctor if you experience

• skin rash or acne;

• mild headaches;

• mild drowsiness or tiredness;

• impotence;

• metallic taste in the mouth; or

• swollen or sore tongue.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.