• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before using diazepam rectal, tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• valproate (Depakene);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

• medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);

• narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with diazepam rectal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if the person receiving this medication has any of these serious side effects:

• worsening seizures, or seizures that seem different from the patient's other seizures;

• pale or discolored skin;

• confusion, unusual thoughts or behavior;

• unusual risk-using behavior, decreased inhibitions, no fear of danger;

• depressed mood, thoughts of suicide or hurting yourself;

• hyperactivity, agitation, hostility;

• hallucinations;

• feeling light-headed, fainting; or

• pain or burning with urination.

Less serious side effects may include:

• drowsiness, tiredness;

• blurred vision;

• sleep problems (insomnia);

• muscle weakness, lack of balance or coordination;

• slurred speech;

• nausea, vomiting, stomach pain, diarrhea;

• headache;

• skin rash; or

• runny nose.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.