• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking cyclophosphamide, tell your doctor if you are taking any other medicines, especially any of the following:

• phenobarbital (Luminal, Solfoton);

• allopurinol (Zyloprim);

• digoxin (Lanoxin);

• warfarin (Coumadin);

• a thiazide diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others; or

• another chemotherapy medicine.

You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Do not receive "live" vaccines during treatment with cyclophosphamide. Administration of a live vaccine may be dangerous during treatment with cyclophosphamide.

Other drugs may interact with cyclophosphamide. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with cyclophosphamide.

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);

• blood in the urine;

• black or tarry stools;

• painful or difficult urination;

• signs of infection such as fever; chills, or sore throat;

• jaundice (yellowing of the skin or eyes);

• lower back or side pain;

• chest pain, difficulty breathing, or swelling;

• unusual bleeding or bruising; or

• changes in bone marrow function (detected by blood tests).

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience

• nausea, vomiting, or decreased appetite;

• mouth sores;

• abdominal pain;

• diarrhea;

• temporary hair loss;

• temporary or permanent sterility;

• rash;

• changes in skin color; or

• changes in nails.

In some cases, secondary cancers have been reported to occur during and following treatment with cyclophosphamide. Talk to your doctor about the risks and benefits of this medication.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.