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Many drugs can interact with codeine and promethazine. Below is just a partial list. Tell your doctor if you are using:

• sedatives or anxiety medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion);

• antidepressants such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil);

• narcotic pain medicines such as meperidine (Demerol), morphine (MS Contin, MSIR), propoxyphene (Darvon, Darvocet), hydrocodone (Lortab, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), codeine (Fiorinal, Fioricet, Tylenol #3);

• phenobarbital (Luminal), amobarbital (Amytal) or secobarbital (Seconal);

• an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or

• atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), methscopolamine (Pamine), and scopolamine (Transderm-Scop).

This list is not complete and there may be other drugs that can interact with codeine and promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• restless muscle movements in your eyes, tongue, jaw, or neck, tremor (uncontrolled shaking);

• shallow breathing, slow heartbeat;

• feeling like you might pass out;

• jaundice (yellowing of the skin or eyes);

• confusion, agitation, hallucinations, unusual thoughts or behavior;

• seizure (convulsions);

• urinating less than usual or not at all; or

• fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing.

Less serious side effects may include:

• dizziness, drowsiness, sleepiness;

• feeling restless, nervous, or anxious;

• blurred vision, ringing in your ears;

• constipation, mild nausea or vomiting;

• warmth, redness, or tingly feeling under your skin;

• sleep problems (insomnia);

• increased sweating;

• dry mouth; or

• mild skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.