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clopidogrel
(kloh PID oh grel)

Before taking clopidogrel, tell your doctor if you are using any of the following drugs:

  • phenytoin (Dilantin);

  • tamoxifen (Nolvadex);

  • tolbutamide (Orinase);

  • torsemide (Demadex);

  • fluvastatin (Lescol);

  • a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or

  • medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), and urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to take clopidogrel, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect clopidogrel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using clopidogrel and call your doctor at once if you have any of these serious side effects:

  • nosebleed or other bleeding that will not stop;

  • black, bloody, or tarry stools;

  • coughing up blood or vomit that looks like coffee grounds;

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  • sudden numbness or weakness, especially on one side of the body;

  • sudden headache, confusion, problems with vision, speech, or balance; or

  • pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual.

Continue taking clopidogrel and talk to your doctor if you have any of these less serious side effects:

  • stomach pain;

  • runny or stuffy nose, cough, sore throat; or

  • mild headache or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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