• Basic Info
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• Interactions

Clofibrate may increase the effects of the following drugs, which could lead to dangerous side effects:

• anticoagulants (blood thinners) such as warfarin (Coumadin); and

• insulin or oral medications used to treat diabetes such as glipizide (Glucotrol), glyburide (Micronase, Diabeta, Glynase), tolbutamide (Orinase) or tolazamide (Tolinase).

Clofibrate is generally not recommended for use with other cholesterol-lowering drugs such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), atorvastatin (Lipitor), and gemfibrozil (Lopid). A serious reaction involving the muscles and kidneys may occur if these drugs are taken together and can result in death.

Drugs other than those listed here may also interact with clofibrate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking clofibrate and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• chest pain or an irregular heart beat;

• severe stomach pain with nausea and vomiting;

• fever and chills, a sore throat, or a flu-like feeling;

• blood in your urine or a decrease in urination;

• swelling of your ankles or legs;

• muscle cramps, muscle weakness, muscle aches, or muscle pain;

• joint pain; or

• sudden weight gain.

Other, less serious side effects may be more likely to occur. Continue to take clofibrate and talk to your doctor if you experience

• bloating or flatulence;

• nausea, vomiting, or diarrhea;

• headache;

• dizziness or drowsiness; or

• impotence.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.