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Drug Notebook

Generic Name: clindamycin

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A lincomycin derivative - used forPerinatal Group B Streptococcal Disease and Bacterial Endocarditis... more

FDA Alerts

Diarrhea and Colitis

Clostridium difficile-associated diarrhea and colitis (antibiotic-associated pseudomembranous colitis) has been reported with nearly all anti-infectives, including clindamycin, and may range in severity from mild to life-threatening. Anti-infectives alter normal flora of the colon and may permit overgrowth of clostridia; a toxin produced by C. difficile is one primary cause of antibiotic-associated colitis.
It is important to consider a diagnosis of C. difficile-associated diarrhea and colitis in patients who develop diarrhea subsequent to clindamycin treatment. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks after cessation of clindamycin therapy.
After a diagnosis of C. difficile-associated diarrhea and colitis has been established, initiate therapeutic measures.

Mild cases usually respond to drug discontinuation alone.

In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an anti-infective clinically effective against C. difficile colitis. (See Superinfection/Clostridium difficile-associated Colitis under Cautions.)
Because clindamycin has been associated with severe colitis (potentially fatal), it should be reserved for treatment of serious infections when less toxic anti-infectives are inappropriate.
Do not use for nonbacterial infections.

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Cleocin HCl
CLEOCIN 300 mg / CLEOCIN 300 mg 300 mg	CLEOCIN 150MG / CLEOCIN 150MG 150 mg
Clindamycin Hydrochloride
cor 153 cor 153 / cor 153 cor 153 150 mg	DAN 5708 / DAN 5708 150 mg	93 3171 / 93 3171 150 mg	cor 154 cor 154 / cor 154 cor 154 300 mg
RX693 RX693 / RX693 RX693 300 mg	DAN 3120 / DAN 3120 300 mg	G 150 mg / 3328 150 mg

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clindamycin

(klin da MYE sin)

There may be other drugs that can affect clindamycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using clindamycin and call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
urinating less than usual or not at all; or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Keep taking clindamycin and talk to your doctor if you have any of these less serious side effects:

mild nausea or stomach pain;
vaginal itching or discharge;
mild skin rash or itching; or
irritation in your throat.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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