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SaveGeneric Name: cisplatin
FDA Alerts-
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Experience of Supervising Clinician
- Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents. Use only when adequate treatment facilities for appropriate management of therapy and complications are available.
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Dose-Related Toxicities
- Risk of dose-related toxicities, including myelosuppression, nausea, vomiting, and cumulative, severe renal toxicity. Dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.
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Ototoxicity
- Risk of ototoxicity; more pronounced in children. Manifestations include tinnitus, loss of high frequency hearing, decreased hearing acuity, and, occasionally, deafness.
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Anaphylaxis
- Risk of anaphylactoid reactions (e.g., facial edema, bronchoconstriction, wheezing, tachycardia, hypotension); may occur within minutes following administration. (See Anaphylactoid Reactions under Cautions.) IV epinephrine, corticosteroids, and antihistamines have been effectively employed to alleviate symptoms.
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Potential Medication Errors
- Avoid accidental, potentially fatal, overdosage due to confusion with carboplatin (Paraplatin®) or due to failure to differentiate daily dosages from total dosage per cycle. Cisplatin dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.
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- Interactions
Before using cisplatin, tell your doctor if you are using any of the following medicines to control seizures:
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carbamazepine (Tegretol, Carbatrol, Epitol);
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phenytoin (Dilantin);
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gabapentin (Neurontin);
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tiagabine (Gabitril);
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valproic acid (Depakene) or divalproex sodium (Depakote);
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lamotrigine (Lamictal);
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felbamate (Felbatol);
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levetiracetam (Keppra);
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primidone (Mysoline);
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zonisamide (Zonegran);
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topiramate (Topamax);
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oxcarbazepine (Trileptal);
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a barbiturate such as mephobarbital (Mebaral) or pentobarbital (Nembutal); or
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a benzodiazepine such as lorazepam (Ativan), diazepam (Diastat, Valium), clonazepam (Klonopin), or clorazepate (Tranxene).
Cisplatin may decrease the effects of medicines used to control seizures and a dosage adjustment may be required.
Drugs other than those listed here may also interact with cisplatin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with cisplatin.
If you experience all of the following serious side effects from cisplatin, contact your doctor immediately:
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an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
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kidney damage (little or no urine production, blood in the urine);
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hearing loss or ringing in the ears;
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decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
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severe nausea, vomiting, diarrhea, and loss of appetite;
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heart and circulation problems;
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gout or increased uric acid in the blood;
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numbness or tingling;
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blurred vision, altered color perception, blindness, and other visual problems;
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liver damage (abdominal pain, yellowing of the skin or eyes); or
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hair loss.
Other side effects have also been reported. Discuss with your doctor any side effect that occurs during treatment with cisplatin.
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