• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking this medication, tell your doctor if you are taking any of the following drugs:

• antacids. Take antacids at least 2 hours before or 2 hours after taking a dose of chlorpromazine. They will decrease the effectiveness of chlorpromazine.

• alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; and seizure medications. All of these medications will increase the side of effects of chlorpromazine-- especially drowsiness and dizziness.

• blood pressure medications such as propranolol (Inderal), methyldopa (Aldomet), and clonidine (Catapres). These drugs may cause dizziness and fainting if used with chlorpromazine.

• anticoagulants such as warfarin (Coumadin). Chlorpromazine may decrease the effectiveness of these medications, and blood clotting could result.

• phenytoin (Dilantin). Chlorpromazine may increase the effectiveness of phenytoin and cause side effects. You may need smaller doses of phenytoin.

Drugs other than those listed here may also interact with chlorpromazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking chlorpromazine and seek emergency medical treatment:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• uncontrollable movements of the tongue, face, lips, arms, or legs;

• muscle spasms of the face or neck;

• severe restlessness or tremor;

• severe drowsiness or fainting;

• a rash; or

• jaundice (yellowing of the skin or eyes).

Other, less serious side effects may be more likely to occur. Continue to take chlorpromazine and talk to your doctor if you experience:

• decreased sweating;

• dry mouth or stuffy nose

• constipation;

• blurred vision

• mild restlessness, drowsiness, or tremor;

• difficult urination or dark urine;

• decreased sex drive;

• dizziness;

• increased appetite; or

• menstrual irregularities or swollen breasts.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.