• Basic Info
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• Interactions

Do not take aspirin/butalbital/caffeine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous sedation could result.

Aspirin/butalbital/caffeine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Dangerous side effects may occur if aspirin is taken with any of the following medicines:

• oral anticoagulants such as warfarin (Coumadin);

• probenecid (Benemid) or sulfinpyrazone (Anturane);

• nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), and naproxen (Naprosyn, Anaprox, Aleve);

• other salicylates (forms of aspirin) such as choline salicylate and magnesium salicylate;

• steroids such as prednisone (Deltasone), prednisolone (Prelone, Pediapred, others), methylprednisolone (Medrol, others), dexamethasone (Decadron), and others; or

• insulin and oral antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase, Diabeta, Glynase).

Do not take this medication without first talking to your doctor if you are taking any of the medications listed above.

Many other medicines contain aspirin, especially over-the-counter pain, fever, cold, and allergy medications. Too much aspirin can be very dangerous.

Drugs other than those listed here may also interact with aspirin/butalbital/caffeine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking aspirin/butalbital/caffeine and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• slow, weak breathing;

• severe weakness or dizziness; or

• black, bloody, or tarry stools or blood in your urine or vomit.

Other, less serious side effects may be more likely to occur. Continue to take aspirin/butalbital/caffeine and talk to your doctor if you experience

• dry mouth, nausea, vomiting, or decreased appetite;

• dizziness, tiredness, or lightheadedness; or

• ringing in your ears.

Butalbital may be habit forming.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.