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The following drugs can interact with acetaminophen, butalbital, and caffeine. Tell your doctor if you are using any of these:

• an antibiotic;

• a blood thinner such as warfarin (Coumadin);

• isoniazid;

• zidovudine (Retrovir, AZT);

• seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton);

• gout medications such as probenecid (Benemid) or sulfinpyrazone;

• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

• steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others; or

• an antidepressant such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), and others.

This list is not complete and there may be other drugs that can interact with acetaminophen, butalbital, and caffeine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heartbeat;

• feeling light-headed or short of breath;

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms.

Less serious side effects may include:

• drowsiness;

• dizziness,, confusion or lightheadedness;

• dry mouth;

• nausea, vomiting, stomach pain, loss of appetite;

• feeling anxious or jittery;

• drunk feeling; or

• headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.