• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before receiving amphotericin B, tell your doctor if you are using any of the following drugs:

• flucytosine (Ancobon);

• digoxin (digitalis, Lanoxin, Lanoxicaps);

• pentamidine (Nebupent, Pentam);

• tacrolimus (Prograf);

• muscle relaxers;

• steroids (prednisone and others);

• antifungal antibiotics such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox);

• antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);

• antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or

• cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid).

This list is not complete and there may be other drugs that can interact with amphotericin B. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if you have a slow heartbeat, chest tightness, or trouble breathing.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor at once if you have any of these serious side effects:

• dry mouth, increased thirst, nausea, vomiting;

• extreme drowsiness, restless feeling, confusion;

• urinating more or less than usual, or not at all;

• muscle pain or weakness, fast or uneven heart rate, feeling light-headed, fainting;

• seizure (convulsions);

• fever, chills, body aches, flu symptoms;

• pale skin, easy bruising or bleeding, unusual weakness; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• pain, swelling, or other irritation where the needle is placed;

• mild nausea, vomiting, diarrhea, upset stomach, loss of appetite;

• weight loss;

• muscle or joint aches;

• headache;

• warmth, redness, or tingly feeling under your skin; or

• skin itching or mild rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.