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Before using almotriptan, tell your doctor if you are using any of the following drugs:

• amiodarone (Cordarone, Pacerone), mibefradil (Posicor), cimetidine (Tagamet);

• ketoconazole (Nizoral), itraconazole (Sporanox), nefazodone (Serzone), clarithromycin (Biaxin), erythromycin (Ery-Tab, Erythrocin, E.E.S, E-Mycin), troleandomycin (Tao);

• HIV medicines such as indinavir (Crixivan), saquinavir (Invirase), lopinavir/ritonavir (Kaletra), ritonavir (Norvir), or nelfinavir (Viracept);

• an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor); or

• another migraine medicine such as naratriptan (Amerge), eletriptan (Relpax), frovatriptan (Frova), sumatriptan (Imitrex), rizatriptan (Maxalt), or zolmitriptan (Zomig).

If you are using any of these drugs, you may not be able to use almotriptan, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect almotriptan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using almotriptan and call your doctor at once if you have any of these serious side effects:

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• fast heart rate, agitation, muscle stiffness, hallucinations, lack of coordination, with nausea, vomiting, or diarrhea;

• sudden and severe stomach pain and bloody diarrhea;

• numbness or tingling and a pale or blue-colored appearance in your fingers or toes.

Continue using almotriptan and talk with your doctor if you have any of these less serious side effects:

• dry mouth, upset stomach;

• mild headache (not a migraine);

• dizziness, sleepiness; or

• pressure or heavy feeling in any part of your body; or

• feeling of pain or pressure in your neck and throat.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.