Drug Notebook

FDA Alerts

  • May cause fetal and neonatal morbidity and mortality if used during pregnancy. (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
  • If pregnancy is detected, discontinue aliskiren as soon as possible.

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aliskiren
(a LIS ke rin)

The following drugs can interact with aliskiren. Tell your doctor if you are using any of these:

  • furosemide (Lasix);

  • antibiotics such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);

  • a potassium supplement such as K-Dur, Klor-Con;

  • salt substitutes that contain potassium; or

  • a diuretic (water pill).

This list is not complete and there may be other drugs not listed that can affect aliskiren. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;

  • nausea with slow uneven heart rate and a weak pulse; or

  • swelling around your eyes.

Less serious side effects may be more likely to occur, such as:

  • stomach pain or upset, diarrhea, heartburn;

  • itching or skin rash;

  • headache, dizziness, tired feeling;

  • back pain, joint pain or swelling; or

  • stuffy nose, sore throat, cough.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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