Medically Reviewed on April 24, 2013 by George Krucik, MD, MBA
Written and medically reviewed by the Healthline Editorial Team
Co-developed by:

In Depth: Pancreas and Spleen

Pancreas

The pancreas is a long gland that extends from the duodenum (the upper portion of the small intestine) to the spleen. It serves both digestive and endocrine functions.

The pancreas aids in digestion by producing enzymes that digest several things, including proteins, fats, carbohydrates, and nucleic acid, a common acid that acts as building block in DNA and is essential for all living things.

The pancreas protects the lining of the small intestine by producing large amounts of alkaline fluid. This base helps neutralize the acid in chyme from the stomach as it enters the small intestine. This fluid collects in a main duct that joins with a common bile duct. The fluid and bile wait to be released into the duodenum when the stomach releases food.

The pancreas also functions as an endocrine gland by producing two very important hormones that help regulate the level of sugar in the blood: insulin and glucagon.

People whose pancreases do not produce enough insulin have a condition known as diabetes. Type 1 diabetics have a pancreas that does not produce insulin, and they must administer the hormone via injections through their skin. Type 2 diabetics still produce a small amount of insulin.

The pancreas can stop producing insulin for various reasons. Poor diet, obesity, and a genetic disposition for the condition are among the most common causes of diabetes.

Spleen

The spleen is a fist-sized organ of the lymphatic system that operates as filter for blood. It helps fight infection and keep body fluids in balance.

This small soft organ has a large blood supply despite its size, and it is important in the body’s fight against infection.

In addition to filtering blood through pulp-like tissue, the spleen also houses two very important types of immunity-related white blood cells: lymphocytes and phagocytes.

Some of the spleen’s other functions include:

  • Cleaning impurities from the blood
  • Destroying old red blood cells
  • Storing blood in case of emergency, such as injury

Because the spleen is soft, it can be injured in an accident, but this is rarely life threatening. If the damage is severe enough, the spleen may need to be surgically removed through a procedure called splenectomy.

Humans can live without a spleen because other organs — such as the liver — can take over the spleen’s function. However, people who have had their spleens removed are at greater risk of infection. 

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