In this medical health video Dr. Insel expresses his hope for the development of "a whole new generation of treatments " using genetics, cell biology and imaging.
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What are your hopes for the future of research? Dr. Thoma Insel: The worldwide research going in the next decade for studies in mental illness. I'm very hopeful. I think this is the really the era for backing away from last 30 years where we've put so much into neuropharmacology of the existing drugs and now asking about pathophysiology of these illnesses, trying to get very clear on what are the mechanism at the genetic level, at the cellular level and at the level of brain systems. We know these can be studied as brain disorder. Now what we need to do, is to actually put the tools in place, to be able to say, how does somebody develop a psychotic response, how does somebody fail to be able to regulate mood, what goes into the whole experience of developing panic disorder Those kinds of questions doing that by using genetic switch, now has become extremely prices ans powerful and we have large scale genetic Projects underway, using Whole-Genome Association all of which will going into public domain, we'll know a lot more about that in 6-7 months, using imaging in a way that's the perhaps a little different than what we've done up until now. To not looking for bloobs FMRI scan, it's following people overtime, that's one thing we've learned about the imaging particularly in development. The most information comes from longitudinal studies of the same subjects, where you can understand how the brain circuitry is changing, how brain regional activity changes over different states in the same individual. I think it's going to tell us an awful lot, we know these are brain disorders. Now where in the brain is the action. What are the, where's the abnormal activity and where do our treatment have their greatest impact. Putting that together with the genetics and some of the cell biology that's coming out, we should be able to develop a whole new generation of treatments.