Using Botox for Hyperhidrosis - Anne's Story How Long Have You Been Taking Botox To Control Your Excessive Sweating? Anne: I’ve been taking Botox treatments for about four years now. It lasts anywhere between three to sometimes eight and nine months on the upside. I have had at last consistently for about six to seven months each time. There are some times, a few times where I can go eight months and stretch it out a little bit, you can kind of tell it, it’s starting to wear off but normally, I have not heard anyone that it’s only lasted for three months.