Dermatologist Dr. Glynis Ablon from the Ablon Skin Institute debuts topical Restylane, a cross-linked hyarulonic acid.
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Topical Cream for Wrinkle Treatment Glynis Ablon: This is actually a product that we did research on. It’s using topical restylane to treat wrinkles. So, you’re putting a cream on the face and the results were amazing. Dr. Andrew Ordon: All right, so right now, we have two things that we could use for wrinkles but we have to inject them. We have Botox which stops the action of muscle fibers, the contraction of the muscles which leads to wrinkles or actually filling wrinkles with hyaluronic acid or other products. You can actually think of it as putting a little spackle. If this is the wrinkle on your face -- I got a pretty good spackle there Jim. This is what you’re doing here; you’re actually filling a line with your spackle. Up until now, to fill these lines, we had to use a needle. So, they’ve come up with something, they’re doing trials out of a product that’s going to hopefully get the same result without using a needle. Glynis Ablon: Well, this is exciting because we actually can use a new system. It’s a new delivery system to put the topical end of a skin and the complaint we usually have with products is they don’t get into the skin and this new delivery system gets into the skin. We did a study; we actually compared the crosslinked hyaluronic acid, the topical restylane with non-cross linked hyaluronic acid and then the vehicle. These are some before and after. These are 90 days and we did the study, patients before and after and you can see this is just a topical cream; no needles, no injections, no pain, put it on at home twice a day. But the most exciting part, at 90 days, we stopped the product. We took the patients 30 days out and we have them come back, the evaluation of their skin with the crosslinked hyaluronic acid, the topical restylane that we used in the study, we saw continued improvement. So, we had dramatic improvement, smoothing of the skin, the texture. It was amazing. Dr. Andrew Ordon: Up until now, people have claimed that they could do this but the molecules are so large that they just can’t penetrate through the skin and that’s really the difference. This system that you’ve developed that allows things to penetrate that normally can’t pass through the skin. Glynis Ablon: Exactly. This is a nanotechnology and nanotechnology, this is one millionth of millimeters, so very tiny, smaller than a pore and so, it actually can penetrate into the skin. It’s called INParT Delivery System. That’s what it was actually developed by Doctor Modi and it is the Ionic Nano Particle Technology. Dr. Andrew Ordon: We’re going to show everybody out there exactly how that works. So, this is a large particle. What they do, they separated into small particles and then cover it with the lipid on the outer surface and that lipid surface is then able to penetrate into the skin, into the dermis where we want these compounds to work, to form collagen, promote new collagen growth. Dr. Travis Stork: I think they’re a lot of women. I got to know how I can get this. Dr. Lisa Masterson: Yeah. I thinks tons of women, when is it going to be available? Dr. Andrew Ordon: I think we all want it. Glynis Ablon: Well, hopefully in the next six months. There are actually two versions. We have the crosslinked hyaluronic acid and that’s what’s been studied and that’s what’s pending, hopefully, in the next six months. The non-crosslinked which also showed great results is -- I believe we have it for your entire audience and it is available Dr. Andrew Ordon: Wow! Dr. Travis Stork: You made some happy people in the audience, many included, why don’t you cheer? Glynis Ablon: But that’s available now Dr. Lisa Masterson: Not now. Dr. James M. Sears: Do I have wrinkles? Dr. Andrew Ordon: Oh, Jim. Dr. Travis Stork: I think we should start with Jim. Dr. Andrew Ordon: Jim, I have some. You get your first treatment right here. Dr. Travis Stork: I think the reason Jim didn’t clap because he wanted some

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