Ludovico Guarini MD Pediatric Hematology Residency Beth Isreal Medical Center .. Fellowship: Coulmbia University .. Director of Pediatric Hematology at Maimonides Medical Center .. Castle Connolly Top Doctor DrMDK.com
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Male Speaker 1: Dr. Cruz is there a disease called Sickle Cell Anemia? Dr. Cruz: Yes, that's actually a disease, another genetic disorder where the hemoglobin is affected. This is somewhat different in what we have just discussed, where instead of having a -- where there is a very specific mutation in the hemoglobin that changes the chemical characteristics of this very essential molecule in the blood, and because of that all kinds of problem ensue. This disease again, the genes come from some place and is specially from places -- the gene originates in Africa, in essentially Central Africa, and then from there has moved to the Mediterranean basin to some degree. There is some level of sickle-cell present in areas like for instance Saudi Arabia, and then obviously, there is sickle-cell present here in the United States, and in a number of other countries where African genes had moved over time. So it is a fairly common problem amongst African-American or individuals from the Caribbean Islands, who have African ancestry. The overall country with Thalassemia where probably the numbers are measured in hundreds to a few thousand here in the United States. There are probably about a hundred thousand patients with sickle-cell disease here in the United States and many people carry the trait -- [Video-end abruptly]

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