The risks associated with VNS are relatively low in comparison to other treatments for depression.
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Question: What are the risks involved with Vagus Nerve Stimulation? Mark S. George: In it's surgery. So you have to, you have cut skin and you can have an infection, but infection rates are pretty low less than 1%. There are actually two incisions, one, here to put this under the skin and that another one in the neck to wrap the wire and then they connect these things under the skin here. Most people don't notice when the device goes on or not. It's not on all the time. It turns itself on and off. If you stimulate for a high intensity, it can cause a subtle change in your voice, kind of like you have a frog in the throat. So, sometimes at high intensity, it cause a little bit of hoarseness in the voice. That's the most common side affect. Other than that it's pretty well tolerated with no other side affects. Unlike medicines, you never leave the town without it. You don't forget and it turns itself on. So, you really don't forget. So, compliance is 100%. That's easy, it's an easy therapy. It doesn't have any other side effects. A lot of the anti-depressant medications that we used caused problems like dry mouth or problems with sexual performance, other problems and so this has really none of those, because it's not a drug. its just a stimulation straight into the brain.