Female Speaker: After her birth to an H.I.V. infected mother Janie Queen was very ill. Clearly, now she feels fine. Janie was one of the first children in the world to be given protease inhibitors, the most powerful anti-H.I.V. drugs yet discovered. Janie takes the protease inhibitors in combination with other drugs five times a day. Janie Queen: In the morning, I go take my medicine. And then in the afternoon, I take it after lunch. I feel good, because it makes you healthy. Female Speaker: Janie came to the Queen family in 1992, nine months old, H.I.V.-infected, and in need of a home. The first few years were rough Janie suffered constant infections, she bruised and bled easily. Then when they became available in 1996, she began taking the protease inhibitors and her world changed completely. Michael & Sandra Queen: Her viral load, you know, has deadly declined and now it's down to zero, or undetectable levels. I mean she's just, she's so healthy, she's so smart. Dr. Mark Kline: You have a hard time describing a child with H.I.V. as being lucky, but Janie is a lucky child with H.I.V. She has the support of a loving family, super parents, and she's benefited from all the recent advances in treatment of H.I.V. Female Speaker: Worldwide, more than 40 million people are infected with H.I.V. Fewer than 2 million of them live in the United States and Western Europe combined. Put another way, more than 95 percent of all cases of H.I.V. are in the developing world. The highest H.I.V. infection rate in this country is in New York City, particularly in neighborhoods such as Harlem and the Bronx, home to the disadvantaged that are now hardest hit by H.I.V. Doctor Wiznia's clinic is in the Jacobi Medical Center in the Bronx. Even here, with a patient count higher than anywhere in the country, clinic workers are able to match the successes in other U.S. clinics. Dr. Andrew Wiznia: Well we are treating a 225 H.I.V. infected children at our site. And of those children, I'd say about half or 50%, when we measure the amount of virus in their blood stream its zero, it's undetectable. Female Speaker 2: How are you doing with your medications? Female Speaker 3: I'm doing good. I just found out last week that I'm undetectable. Female Speaker 2: I know. Female Speaker 3: That my t-cells went up to 103, so that means the medicine's working. Female Speaker 2: Great! Female Speaker 1: This 15-year-old girl suffered through a very sickly childhood, until doctors finally ordered an H.I.V. test at age 13. Her counselor was with her when the results came in. Female Speaker 3: She went in and she looked what happened but when she came back out she was crying, so I already knew I had it. Female Speaker 1: She was started on the latest anti-H.I.V. drugs immediately, with amazing results H.I.V. tests cannot find any virus in her body. Dr. Andrew Wiznia: We try to develop a treatment that will turn the virus off. It's not curing the virus, but it's suppressing the virus, it's keeping it in a box, and preventing the virus from growing. By keeping it in a box, the baby will then grow up and have a normal immune system. Dr. Mark Kline: We can preserve immune function, and we can restore to health children who literally, in some cases, were on their deathbeds. It's not just that the child has to take a pill; it's that the pill has to be taken in a certain way. It has to be taken at certain intervals. And it has to be done day in and day out. And I think anyone who's had ten days of an antibiotic for an ear infection or a throat infection knows how difficult it is to remember to take medicine even for ten days, so you can imagine how difficult it is to do this literally over your entire lifetime. Female Speaker 3: I used to play around with my medicine. I used to throw them in the trashcan, flush them down the toilet, and make believe I took them. Dr. Mark Kline: Children want to be normal, they want to be like every other child and H.I.V. sets them apart, taking