Michael Marcus, MD , talks about the facts and stats of the flu vaccine.
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It was recommended that all Health Care Professional should be vaccinated and that this includes Medical Professionals as well as other workers who are in the hospital and outpatient settings, medical emergency-response workers as well as everybody training. And so if you're a work-clerk working in a hospital, if you're a secretary working in a hospital, if you're in a healthcare setting, you're going to transmit and share virus. You should be vaccinated. And as you have heard New York state is taking one step further and it has how mandated vaccination across the hospitals. And it's because of this, when we take a look at the pediatric population which should be the easiest population of vaccinating because they are used to coming in for vaccines. We are very, very poor, less than 50% of the population who should be vaccinated, ever get vaccinated in any given year. This was '06, this has been mirrored year after year, year, we are not very good in getting kids back in to get vaccinated. It's a narrow window, vaccine is only available for a period of October through February or March. Kids come in the summer for their preschool camp physicals, they don't remember to come back in, we are busy, they come in and they are seeking, don't give it to them and they don't come back. All the reasons and excuses but ultimately, we only vaccinate half of the kids and even more worrisome is of the children who get one vaccine. If they're less than anything, they need a booster four weeks later. You see, less than 25% of them ever get their second booster. So they are not protected in that first year. And the rule is if you get in your first year, if your eights years in age and under, you need two vaccines, four weeks apart. If you don't get two vaccines in the first year than in your second year, you should get two vaccines four weeks apart. If you don't get in your second year, the third year you are down to just one vaccine because you had two years leaving up to, so you don't need that second vaccine in the third year performance. But you try to get that second vaccine in -- or before the second year at the end of the day. What vaccines we have available? Well, there are really two forms, we have this standard trivalent and you have the live attenuated influenza vaccine, FDA approved these in the years that you see with our trivalent since the 60s, the live attenuated since 2003. The relative administration is different, the route administration is into muscular versus intranasal, and the difference relates to the humoral response. You get only humoral response, IGG response, with the standard chilled trivalent vaccine where we get a mucosal cellular response, T-cell response as well as that, immunoglobulin response with that. I'll show you why in just a moment. But it really comes down to what you are giving. Ultimately, you are giving subunits that are in affidavit, that are standardized leukemia gluten, whereas with the live attenuated you are giving an adapted whole virus particle. So you are giving the entire virus which is stimulating full immunologic response as opposed to just immunoglobulin response. Their growth medium is same, they are both growing chickened. If you're neutralizing antibody to the hemoglobin, but with a fly virus since it has the potential to replicate, it has other epitopes, you get a more complete immunologic response stimulating your cellular immune system, the T-cell and mucosal portion of the response, not just the B-cell. You are also going to have active antibody to neuraminidase as well as the other internal proteins which will not be present in the enactment. And really the reason is supported because cytokine involves and as I alluded to earlier cytokine storm is an important part of what makes us sick, and in some cases of mortality. Influenza or the localize will cause the release of a number of cytokines and it looks like IL-6 and TNF-alpha are two of the most important which are responsibl