EmpowHer Asks: Will a woman gain weight if she has her thyroid removed? David Terris, MD Surgical Director, MCG Thyroid Center Augusta, GA Typically, you shouldn’t gain weight following the thyroidectomy, and the reason is we replace the function of the thyroid with a thyroid hormone and that prevents that problem. If you didn’t take thyroid hormone after your thyroidectomy, then yes, in fact, you could potentially put on weight, but typically, no.