In this medical video learn how finding a treatment that attacks the cause of diabetes is a lofty goal but researchers may have done just that.
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Jennifer Matthews: Treating Type-2 diabetes has been a tough challenge for doctors. Dr. Steven Shoelson: None of the currently available medications are perfect, and one of the biggest problems we have with the current medications is they don't really treat the basic problem. Jennifer Matthews: But Dr. Steve Shoelson says the drug Salsalate could change that. It's an anti-inflammatory drug for arthritis that's been around since the 1800s. Dr. Steven Shoelson: It is strange that we are using a drug that has been around for a long time to treat a disease that has been around for a long time. Jennifer Matthews: New research shows a protein that triggers inflammation is turned on in overweight people. The inflammation leads to insulin resistance and type 2 diabetes. Salsalate shuts off that protein. Dr. Steven Shoelson: We think getting at the cause may have beneficial effects that we have not even anticipated. Jennifer Matthews: An early study shows the drug significantly improves blood sugar levels. Female Speaker: The people who got no drug at all had absolutely no change in their blood sugars. Jennifer Matthews: Jerry Silva was in that early study and saw his blood sugars drop. Jerry Silva: I tend to be the kind of person who doesn't like to take medications if I don't have to. Jennifer Matthews: Since the study ended, he's lost 20 pounds. Instead of drugs, he now controls his diabetes with diet and exercise. Jerry Silva: If I can't walk around anymore or if my body stops responding positively to natural ways of reducing it; this is something I would definitely consider taking. Jennifer Matthews: A large study is now underway to find out how much impact this drug will have. This is Jennifer Matthews reporting. Jennifer Matthews: Treating Type-2 diabetes has been a tough challenge for doctors. Dr. Steven Shoelson: None of the currently available medications are perfect, and one of the biggest problems we have with the current medications is they don't really treat the basic problem. Jennifer Matthews: But Dr. Steve Shoelson says the drug Salsalate could change that. It's an anti-inflammatory drug for arthritis that's been around since the 1800s. Dr. Steven Shoelson: It is strange that we are using a drug that has been around for a long time to treat a disease that has been around for a long time. Jennifer Matthews: New research shows a protein that triggers inflammation is turned on in overweight people. The inflammation leads to insulin resistance and type 2 diabetes. Salsalate shuts off that protein. Dr. Steven Shoelson: We think getting at the cause may have beneficial effects that we have not even anticipated. Jennifer Matthews: An early study shows the drug significantly improves blood sugar levels. Female Speaker: The people who got no drug at all had absolutely no change in their blood sugars. Jennifer Matthews: Jerry Silva was in that early study and saw his blood sugars drop. Jerry Silva: I tend to be the kind of person who doesn't like to take medications if I don't have to. Jennifer Matthews: Since the study ended, he's lost 20 pounds. Instead of drugs, he now controls his diabetes with diet and exercise. Jerry Silva: If I can't walk around anymore or if my body stops responding positively to natural ways of reducing it; this is something I would definitely consider taking. Jennifer Matthews: A large study is now underway to find out how much impact this drug will have. This is Jennifer Matthews reporting.

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