Male Speaker: The ultimate proof would be someone going down and looking at the tissue. Martin D. Fried: An endoscopy and a small intestine biopsy, the test is small little forceps through the scope and they take a small little tissue from different areas of the small intestine. Male Speaker: It normally unhealthy tissues like little... Martin D. Fried: Villi. Male Speaker: Villi up there and if they have the disease it's like... Martin D. Fried: The villi is now longer able to absorb food they go flat like that. Male Speaker: And if therapy is successful, you go back later on, the villi are back Martin D. Fried: Then villi have returned? Yes. Male Speaker: That's why if you do the therapy and some will look down and because the therapy without making a appropriate diagnosis you say the kid is normal. That's why it's important to make to diagnose initially, but we are not talking major surgery are we? Martin D. Fried: No, it's passing the scope under anesthesia, the child is sedated, it is a very quick and efficient test. Male Speaker: Since we have done a high risk test, people think we are doing maybe it is like brain surgery. Martin D. Fried: One of the safest test, an endoscopy is one of the safest test you can do. Male Speaker: So in other words it make a lot of sense. So if you are contemplating the diagnosis testing should be done in the lab and it's very important to do the test looking at the tissue.