Well, I would say that one never knows for sure. Uncertainty is perhaps the most delusive thing that one ever can think of so we never know anything for sure. But, if you’re feeling well, you’re doing well and you have no reason to think that anything is out, then I think you know you’re probably close. If you’re not feeling well, then it’s a good time to think about whether you’re on the right hormones or not. Within reason, a variety of different ways of giving hormones are going to lead to good results.