Glucosamine and Chondroitin

The most common supplements are various herbal remedies, glucosamine, and chondroitin. The herbal remedies have many possible modes of action, and people use them primarily for pain relief. Some believe that glucosamine and chondroitin possess joint protection properties, because each is a component of cartilage (a connective tissue in the body).

One study suggests that the use of glucosamine sulfate decreases the loss of cartilage in patients with osteoarthritis of the knee, while other studies demonstrate improved function and pain reduction with doses of 1500mg. per day (Reginster et al. 2001; Noack et al. 1994). Arthritis patients usually take nonsteroidal anti-inflammatory drugs (NSAIDs) to help reduce pain and swelling. Several studies have shown that glucosamine has similar pain-reducing properties, without the adverse side effects of NSAIDs (MÜller-FaΒbender et al. 1994; Qui et al. 1998). The primary side effect of glucosamine is gastrointestinal upset, and not all people respond to its use. Although less research exists on chondroitin, studies do provide evidence that chondroitin can reduce pain in people using 1200 mg. per day.

Several people tell me how beneficial glucosamine has been for them. One woman who has difficulty taking NSAIDs swears that glucosamine allows her to keep active. A piano teacher says she can tell the difference when she does not take glucosamine. Glucosamine seems to be most effective for those who have mild to moderate arthritis, and it may be worth trying because of the reduced side effects.