Dealing with Wasting in HIV D... Video Transcript

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Dealing with Wasting in HIV Disease
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Nitrogen is an important part of amino acids, which are the building blocks of protein, and therefore the building blocks of muscle and lean body mass.

ANNOUNCER: One human growth hormone produced by recombinant DNA technology, called Serostim®, is approved for the treatment of HIV wasting.

It may not be appropriate in patients who have diabetes or pre-diabetic conditions.

BRUCE POLSKY, MD: It's actually pretty well tolerated, but there are several side effects that are worth noting. The most prominent one is a recruitment of fluid, of water, into the subcutaneous tissues that can result in joint stiffness. It often will go away in time.

Growth hormone not only stimulates muscle mass and loss of fat, it also stimulates the cartilage, tendons, to grow. When you do that in an adult that is fully developed and has no more skeleton to develop, you may get these sorts of effects, which can be uncomfortable. They can be controlled by lowering the dose, or as I said, they often disappear on their own with time.

ANNOUNCER: There's some debate about how common serious weight loss and cachexia are among people with HIV, especially when the disease is under control. But when problems do occur, doctors say they can treat the cause effectively, and help speed recovery.

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