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, James W. Freston MD, PhD, David R. Marks MD, M. Michael Wolfe MD, Eric R. Lemmer MD, PhD
Heartburn can be a nuisance at any time of day, but for many people the greatest frustration happens at night. Not only can heartburn get in the way of a good night's sleep, but going to bed can actually make heartburn worse, even if you're on medication. Join our panel as they talk about nighttime heartburn, and what you can do to fight it.
DAVID R. MARKS, MD: Hi, and welcome to our webcast. I'm Dr. David Marks.
Heartburn can be a nuisance at any time of the day.
But for many people, the greatest frustration happens at night.
Not only can heartburn get in the way of a good night's sleep, but
going to bed can actually make your heartburn worse, even if
you're on medication. Now, joining me to
talk about nighttime heartburn and what you can do about are two
experts. First is Dr. Jim Freston from the University of
Connecticut, welcome.
JAMES FRESTON, MD, PhD:
Okay. DAVID R. MARKS, MD: And next to him is Dr. Michael
Wolfe, and he is from Boston University School of Medicine.
Welcome. MICHAEL WOLFE, MD: Thank you. DAVID R. MARKS,
MD: How big a problem is this? MICHAEL WOLFE,
MD: It's actually more of a problem than previously
recognized. We used to think of heartburn as occurring only
after meals. And, actually, in many situations, was more
bothersome at night than during the daytime. DAVID R. MARKS,
MD: What is it that happens, that cause the
pain? JAMES FRESTON, MD, PhD: Well, acid coming up into the
esophagus -- where acid doesn't belong -- is what causes the
pain. When one is lying down at night, one doesn't have
gravity to pull the acid back down in the stomach, like if you were
upright. The other thing is, when one is asleep, there is less
swallowing. Swallowing clears the esophagus of acid, and also
saliva helps neutralize the acid. MICHAEL WOLFE,
MD: A natural antacid. Saliva has
-- DAVID R. MARKS, MD: Saliva. MICHAEL WOLFE,
MD: -- has bicarbonate inside it. DAVID R. MARKS,
MD: And it's free. MICHAEL WOLFE,
MD: It's free. DAVID R. MARKS,
MD: Now, we all think that medication -- medication does work
very well for heartburn. And we probably think that it helps us
all the time. But, in some cases, at night, it -- you get some
breakthrough. How -- is that a common
situation. MICHAEL WOLFE, MD: Well, the classic example are the
proton pump inhibitors. They're wonderful medication,
and most people actually do get by by taking one pill a day in the
morning. But there's significant number of people who
actually will breakthrough at night. So-called "nocturnal acid
breakthrough." And it'll occur right in the middle of
the night, when someone is sound asleep. Not a good way to start
the next day.
DAVID R. MARKS, MD: But if these
medications are turning off the acid production, how is there acid
that's actually there to get through? JAMES FRESTON, MD,
PhD: Well, in the case of the proton pump inhibitors that
Michael just mentioned, they're taken in the morning.
And their effect gradually does wear off. But then, as their
effect is wearing off, remember now the patient is recumbent. Or
the person is recumbent. And those factors I had mentioned
earlier, that drive heartburn, kick in. They're not
operating necessarily during the day. DAVID R. MARKS,
MD: So what should a person do? MICHAEL WOLFE,
MD: Well, there's several different maneuvers one can
take to avoid --
DAVID R.