Thymus Cancer

Written by Jaime Herndon | Published on July 19, 2012
Medically Reviewed by Brenda B. Spriggs, MD, MPH, FACP

Thymus Cancer

The thymus gland is an organ in your chest, underneath the breastbone. It is part of the lymphatic system, which is part of your body’s immune system. The thymus gland produces white blood cells called lymphocytes. Lymphocytes help your body fight infection.

There are two main kinds of thymus cancer: thymoma and thymic carcinoma. These are rare cancers. Thymic carcinoma is more aggressive and more difficult to treat than thymoma. Individuals with a thymoma typically have an autoimmune disease as well. Thymic carcinoma is also referred to as type C thymoma.

The cause of thymus cancer is unknown, but it is more common in middle-aged adults.

Symptoms of Thymus Cancer

According to the American Cancer Society, roughly four out of 10 people have no symptoms when they are diagnosed with thymus cancer (ACS, 2012). Many times, cancer is found during other medical tests or exams. When symptoms do occur, they may include a persistent cough, breathing difficulties, or chest pain. Because of how nonspecific the symptoms are, diagnosis can be delayed.

How Is Thymus Cancer Diagnosed?

A general physical exam will be done to see if there are any unusual findings such as lumps. Other tests used to diagnose thymus cancer include:

  • chest X-ray
  • imaging tests such as positron emission tomography (PET) scan, computed tomography (CT) scan, and magnetic resonance imaging (MRI)
  • biopsy with microscopic examination of thymus cells

There is no single agreed-upon staging system for thymomas. A staging system is a method of classifying cancer based on its size, extent, and other characteristics. Many doctors use the Masaoka staging system, which organizes the disease into Stage I through Stage IV. Stage I is noninvasive. In Stage IV, the cancer has spread to distant organs such as the liver or kidneys.

Treatment for these cancers depends on the extent of disease, which is indicated by its stage, as well as the overall health of the individual. Although thymic carcinoma is typically widespread at the time of diagnosis, this staging system may be used.

Treatment for Thymus Cancer

There are several treatments available for thymus cancer, depending on the stage of disease. A treatment plan may include more than one kind of treatment.

Surgery is the surest way to eliminate the cancer and is performed whenever possible to remove the tumor, thymus gland, or other diseased tissues. If the cancer is too large or has spread too far to be completely removed, the doctor may recommend radiation to shrink the tumor first and then operate. He or she may also decide to remove as much cancer as possible and then proceed with another treatment option.

Radiation or chemotherapy may be given before or after surgery. Radiation uses high-energy X-rays to kill cancer cells by damaging their DNA. Chemotherapy involves the use of drugs to kill cancer cells. Chemotherapy drugs are usually given intravenously (through a vein). This enables the medication to work throughout the entire body, killing cancer that may have spread to other areas.

Hormone therapy is another treatment option for thymus cancers. Some hormones cause the cancer to grow. If your cancer is found to have hormone receptors (places for hormones to attach), drugs may be given to block the action of hormones on the cancer cells.

Because thymus cancer is so rare, you might want to ask your doctor about taking part in a clinical trial. These are trials in which new treatments for the cancer are prescribed to help determine their effectiveness. Participants are closely monitored and they can discontinue their participation at any time. Clinical trials are not right for everyone, but your doctor can tell you whether this is an option for you.

After Treatment

Long-term outlook for these cancers depends on a multitude of factors, including your age and overall health, whether surgery removed all of the tumor, the type of cancer cells present, and the stage of disease. Once treatment is over, follow-up visits are necessary. This is to monitor you for any side effects from the treatment and to ensure that the cancer has not returned.

The risk of the cancer returning is very real, and this can be a source of anxiety for patients. Ask your doctor about support groups or counseling if you find yourself struggling emotionally or feel like you might want to talk to someone.

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