If you have diabetes, you’re at a higher risk for heart disease and stroke. This makes it especially important to control other risk factors for cardiovascular problems, such as high cholesterol. Fortunately, there are medications called statins that are quite effective at lowering your low-density lipoprotein (LDL), or “bad” cholesterol.
Which statin is most appropriate if you have diabetes? It depends on your overall cardiovascular risk, but the recommendations lean toward a moderate-intensity or high-intensity statin.
There are several different types of statins. Some are more potent than others. They each work a little differently, but they all help lower cholesterol by interfering with a substance your body needs to make cholesterol in the liver.
Statins have become some of the most widely prescribed medications in the world. They include atorvastatin (Lipitor), rosuvastatin (Crestor), as well as other generic and brand name versions.
The optimal LDL level for most healthy people is between 70 and 100 mg/dL. If your LDL numbers exceed that range, your doctor should look at your overall heart disease and stroke risk to decide whether you should be placed on statins.
Recent guidelines presented by the American College of Cardiology and the American Heart Association expanded the number of potential statin users. Doctors used to base their decision to prescribe a statin primarily on a person’s LDL score. Now, other risk factors are also considered. In general, statins are usually recommended for people who have:
- diagnosed cardiovascular disease
- an LDL cholesterol level of 190 mg/dL or higher
- diabetes and an LDL of 70 mg/dL or higher
- a 10-year heart attack risk of 7.5 percent or higher and an LDL of at least 100 mg/dL
Diabetes and stains
In 2014, the American Diabetes Association recommended that all people with diabetes take statins. Their reasoning is that controlling risk factors will help lower your overall risk for developing heart disease. These risk factors may include:
- high cholesterol
- high blood pressure
- being overweight or obese
- a high level of sodium in your diet
- a low level of physical activity
The fewer risk factors you have, the better your odds of avoiding a heart attack or stroke.
Diabetes is a threat to your cardiovascular health partly because the extra glucose in your blood can injure your blood vessels. When your blood vessels are damaged, blood flow to the heart and brain can be disrupted. This raises the risk of a heart attack or stroke.
Diabetes can also affect your cholesterol. If you have diabetes, you should at least consider statin therapy, even if your diabetes is well controlled.
Choosing a statin
The right statin for you will partly depend on your LDL level. If your cholesterol is only slightly elevated above what your doctor thinks is a good target for you, a less potent statin might be what you need. Pravastatin (Pravachol) and lovastatin (Altoprev, Mevacor) are good lower potency options.
If you need to combat high cholesterol more aggressively, your doctor may prescribe rosuvastatin (Crestor), which is the most powerful statin. Atorvastatin (Lipitor) and simvastatin (Zocor) have moderate potency.
Your ability to tolerate a particular statin is also an important consideration. Your doctor may start you on a strong statin and switch the type of statin or lower your dosage, if needed. Some doctors, however, choose to start with the mildest option and work their way up if a patient’s cholesterol numbers don’t come down enough.
Even though statins are usually well tolerated, they do have some side effects. The main complaint statin users have is muscle pain. This is called myalgia. Switching to a different type of statin or a lower dose often solves the problem.
For people who have diabetes or who are at a higher risk of developing diabetes, there’s another statin side effect that may be of greater concern. The Food and Drug Administration (FDA) reports that statin use can lead to a slight increase in blood sugar levels. This may be a concern for a person with diabetes or someone who is at increased risk of developing diabetes.
The FDA, however, also notes that because the cholesterol-lowering benefits of statins are so profound, this risk shouldn’t necessarily keep someone from taking statins.
Talk with your doctor
Managing your cholesterol and diabetes shouldn’t be done through medications alone. You and your healthcare provider should discuss other ways, such as exercise and diet, to help control your blood glucose and LDL levels.
If your LDL numbers are high and you have diabetes, consider statin therapy. You should talk to your doctor about:
- your target levels of LDL cholesterol
- the risks and benefits of statins
- the side effects of statins
- how to respond to the side effects of statins
There are several ways to help improve your heart health, but if you have diabetes, aggressive statin therapy may be one of the best things you can do to help prevent a heart attack and stroke.