Skin Lesion Biopsy

Written by Brian Krans | Published on July 16, 2012
Medically Reviewed by George Krucik, MD

What Is a Skin Lesion Biopsy?

A skin lesion biopsy is a simple medical procedure in which a sample of your skin is removed and tested in a laboratory.

The sample taken during a biopsy is often very small—often the size of a grain of rice. The sample size is just large enough for laboratory technicians to test for various issues that could be the cause of a skin lesion.

There are several different ways your doctor can collect a skin sample. The procedure your doctor chooses will be dependant on your individual circumstances.

A dermatologist—a doctor who specializes in skin—is typically the doctor who performs a skin biopsy. It is an outpatient procedure.

Why Is a Skin Lesion Biopsy Done?

A skin biopsy is performed to help determine the cause of a growth or sore. This could include:

  • changing moles
  • chronic bacterial or fungal skin infection
  • noncancerous growths
  • precancerous cells
  • skin cancer

The Risks of a Skin Lesion Biopsy

Any medical procedure that involves breaking the skin involves the risks of bleeding and infection. If you have a history of bleeding problems, you should inform your doctor.

There is also a risk of scarring. If your doctor uses an excisional biopsy, you may have a small scar after the procedure. Other biopsy types rarely leave noticeable scars.

How a Skin Lesion Biopsy Is Performed

A skin lesion biopsy requires little preparation from the patient. If you’re having a biopsy done on an open wound or infected patch of skin, your doctor will have to remove any bandaging.

There are several ways your doctor may remove a sample of tissue. The method your doctor chooses for you will depend on the reason for the biopsy, and the location, size, and type of your lesion or sore.

Before any type of biopsy, you’ll receive local anesthesia to numb the incision site.

Possible methods of collecting a skin sample for biopsy include:

  • shave biopsy: your doctor will remove only the outermost layers of your skin
  • punch biopsy: uses a small, tube-like instrument with a sharp end that works like a cookie cutter. Once the right sample is taken, your doctor will remove the skin sample with tweezers and close the incision with a single stitch
  • excisional biopsy: used to remove the entire lesion. Your doctor makes an incision, and going as deeply as necessary, removes the entire lesion. Several stitches are used to close the wound
  • incisional biopsy: used to remove a small part of a larger lesion. The procedure is the same as with the excisional biopsy

If your doctor suspects a growth is caused by melanoma, the most aggressive form of skin cancer, he or she will use an excisional biopsy to remove any potentially cancerous tissue. The sample will then be sent to the lab for testing.

After the biopsy, the wound will be covered with gauze and other bandaging. You’ll be able to leave once the sample has been taken.

After a Skin Lesion Biopsy

After the tissue sample is taken, it is sent to a laboratory for testing. It could take from a few days to a few weeks for the results to come back. If it is an emergency situation, such as the case of an aggressive infection, your doctor may put a rush on the results.

When the results of your tests are back, your doctor may discuss them with you over the phone or call you into his or her office for a follow-up appointment to share the results.

If your results show signs of cancer or other problems, your doctor will discuss the next course of action, which may include other tests or treatments.

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