Several factors make some women more susceptible to PPROM than others. These include:

  • history of PPROM or preterm birth;
  • vaginal bleeding in the second trimester;
  • smoking;
  • use of steroid medications;
  • diseases that interfere with the quality of connective tissue (such as Ehlers-Danlos syndrome);
  • bacterial infections in the cervix-such as gonorrhea, chlamydia, and bacterial vaginosis-that cause an imbalance of the normal environment of the vagina;
  • cerclage;
  • history of cervical surgery; and
  • abnormalities in the shape or size of the uterus or cervix.