How Does A Lupus Prognosis Affect My Life Expectancy?

Lupus Prognosis: How Does It Affect My Life Expectancy?

Lupus Isn’t Lethal

Lupus is an autoimmune disease, meaning that the immune system attacks the body’s organs, causing damage and organ failure. Over 90 percent of people with lupus are women between the ages of 15 and 45. 

Historically, lupus caused people to die young. Today, with careful treatment, 80 to 90 percent of people with lupus can expect to live a normal lifespan.

“We have found that with treatment, Lupus patients are able to live longer,” said Dr. Olivia Ghaw, Assistant Professor of Medicine, Division of Rheumatology at the Icahn School of Medicine at Mount Sinai, in an interview with Healthline. “They are able to live with less disability and morbidity.”


Lupus always causes some amount of inflammation. Sometimes the lupus can flare up, making symptoms grow more severe. Flares can include joint pain, skin rash, and organ troubles, particularly in the kidneys. 

Proper use of medication can control flares and prevent them from causing lasting organ damage. You’ll want to work closely with your physician to address these symptoms.


Kidneys are the organs most commonly affected by lupus. Long-term inflammation in the kidneys causes damage. If enough of the kidney becomes scarred, it will begin to lose function.

By catching a flare-up early and treating it with the right medications, you can protect your kidneys from damage.


Now that most lupus patients take their medications carefully, they are no longer dying from lupus itself or from kidney failure. However, these patients are still at increased risk of heart disease.

Lupus causes inflammation of the heart, resulting in an increased rate of heart attacks and artery disease, even in young patients in their 20s. Inflammation in the lining of the heart can also cause chest pain.


People with lupus have a greater likelihood of developing anemia or blood clots. Some people with lupus also have antiphospholipid antibody syndrome (APS). APS increases the risk of developing blood clots. 

Blood clots can occur anywhere in the body, including the lungs, the legs, or even in the brain.


Sometimes, the inflammation spreads to the brain. This can present as headaches, mental problems like memory loss or poor concentration, seizures, meningitis, or even a coma. 

Some lupus patients also experience changes in their mood, particularly with irritability, depression, and anxiety.


Some lupus patients develop pleuritis, which is inflammation of the lining of the lungs. Pleuritis causes sharp chest pains when you inhale.

If the inflammation spreads to the lungs themselves, they can become scarred. Lung scarring decreases the amount of oxygen that the bloodstream absorbs.


People with lupus commonly have inflammatory arthritis. They wake up in the morning with stiffness and swelling in their joints, usually in the small joints of the hands. “Sometimes the pain can be very disabling,” said Ghaw.

Unlike some other forms of arthritis, inflammatory arthritis from lupus doesn’t deform the hands.

Digestive System

The inflammation from lupus can spread to the digestive system, hitting organs like the pancreas and the liver.

Lupus can also cause protein-losing enteropathy, in which the gut leaks protein, causing diarrhea and reducing the amount of nutrients that get absorbed.


The same drugs that prevent the immune system from attacking the body also impair its ability to fight off infections. People with lupus are highly prone to infections, including skin infections and urinary tract infections. They could even get sepsis, in which the infection spreads through the entire body.

“Because the body’s immune system is weakened by the drugs, the body is unable to fight off even a simple infection, and a simple infection can become a complex infection, leading to death,” said Ghaw.


People with lupus tend not to have trouble getting pregnant. However, conceiving when lupus is quiet tends to result in healthier pregnancies. Lupus does cause some risk of going into labor early.

Because lupus is influenced by female sex hormones, pregnancy can affect the severity of a woman’s lupus. According to Ghaw, about a third of lupus patients experience a flare-up during pregnancy, a third experience no change, and a third actually see their symptoms improve.

Lifestyle Changes­

Certain lifestyle changes can help improve outcomes of lupus. The greatest risk is of cardiovascular disease, and for this reason, Ghaw recommends eating a heart-healthy diet. 

Stopping smoking and losing weight (if you’re overweight) both lead to much better outcomes. Regular, low-impact exercise tends to help with joint health as well as weight loss.

“People should be in very good contact and communication with their rheumatologist,” said Ghaw. “It’s much easier to prevent complications of lupus rather than treat them afterwards. Hopefully, with lifestyle modifications and the right modifications, they can attenuate the risk of these complications in the future.”

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