What Are Intramuscular Injections?


An intramuscular injection is a technique used to deliver a medication deep into the muscles. This allows the medication to be absorbed into the bloodstream quickly. You may have received an intramuscular injection at a doctor’s office the last time you got a vaccine, like the flu shot.

In some cases, a person may also self-administer an intramuscular injection. For example, certain drugs that treat multiple sclerosis or rheumatoid arthritis may require self-injection.



What Are Intramuscular Injections Used For?

Intramuscular injections are a common practice in modern medicine. They’re used to deliver drugs and vaccines. Several drugs and almost all injectable vaccines are delivered this way.

Intramuscular injections are used when other types of delivery methods are not recommended. These include oral (swallowed into the stomach), intravenous (injected into the vein), and subcutaneous (injected into the fatty tissue just under the layer of skin). Intramuscular injection may be used instead of intravenous injection because some drugs are irritating to veins or because a suitable vein cannot be located. It may be used instead of oral delivery because some drugs are destroyed by the digestive system when a drug is swallowed.

Intramuscular injection is absorbed faster than subcutaneous injection. This is because muscle tissue has a greater blood supply than the tissue just under the skin. Muscle tissue can also hold a larger volume of medication than subcutaneous tissue.


Injection Sites

Intramuscular Injection Sites

Intramuscular injections are often given in the following areas:

Deltoid muscle of the arm

The deltoid muscle is the site most typically used for vaccines. However, this site is not common for self-injection, because its small muscle mass limits the volume of medication that can be injected (typically no more than 1ml). It’s also difficult to use this site for self-injection. A caregiver, friend or family member can assist with injections into this muscle.

To locate this site, feel for the bone (acromion process) that is located at the top of the upper arm.  The correct area to give the injection is two finger widths below the acromion process.  At the bottom of the two fingers, will be an upside down triangle.  Give the injection in the center of the triangle. 


Vastus lateralis muscle of the thigh

The thigh may be used when the other sites are not available or if you need to administer the medication on your own.

Divide the upper thigh into three equal parts. Located the middle of these three sections. The injection should go into the outer top portion of this section.

vastus lateralis

Ventrogluteal muscle of the hip

The ventrogluteal muscle is the safest site for adults and children older than seven months. It’s deep and not close to any major blood vessels and nerves. This site is difficult for self-injection, and may require the help of a friend, family member or caregiver.

Place the heel of your hand on the hip of the person receiving the injection, with the fingers pointing towards their head. Position the fingers so the thumb points towards the groin and you feel the pelvis under your pinky finger. Spread your index and middle fingers in a slight “V” shape, and inject the needle into the middle of that “V”.


Dorsogluteal muscles of the buttocks

The dorsogluteal muscle of the buttocks is the site most commonly selected by healthcare providers. It’s difficult to use this site for self-injection.

Divide the buttock into four equal quadrants, halfway down from top to bottom and halfway across. The injection should always go into the upper, outer quadrant of the buttock, towards the hip bone.


You should not use an injection site that has evidence of infection or injury. If you will be giving the injection more than once, make sure to rotate injection sites to avoid injury or discomfort to the muscles. For example, if you are injecting into the buttocks, use the left side one day and the right side the next.


How To

How to Administer an Intramuscular Injection

Any person who administers intramuscular injections should receive training and education on proper injection technique. The needle size and injection site will depend on many factors. These include the age and size of the person receiving the medication, and the volume and type of medication. Your doctor or pharmacist will give you specific guidelines about which needle and syringe are appropriate to administer your medication.

The needle should be long enough to reach the muscle without penetrating the nerves and blood vessels underneath. Generally, needles should be one inch to one and a half inches for an adult, and will be smaller for a child. They will be 22 gauge to 25 gauge thick (noted as 22g on the packaging).

Follow these steps for a safe intramuscular injection:

1) Wash your hands. Wash your hands with soap and warm water to prevent potential infection. Be sure to thoroughly scrub between fingers, on the backs of hands, and under fingernails. The Centers for Disease Control and Prevention (CDC) recommends lathering for 20 seconds – the time it takes to sing the “Happy Birthday” song twice.

2) Gather all needed supplies. Assemble the following supplies:

  • needle and syringe with medication
  • alcohol pads
  • gauze
  • puncture-resistant container to discard the used needles and syringe (typically a red, plastic “sharp’s container”)
  • bandages

3) Locate injection site. To isolate the muscle and target where you will place the injection, spread the skin at the injection site between two fingers  The person receiving the injection should get into a position that’s comfortable, provides easy access to the location, and keeps the muscles relaxed.

4) Clean injection site. Clean the site selected for injection with an alcohol swab and allow the skin to air dry.

5) Prepare syringe with medication.

Remove the cap. If the vial or pen is multi-dose, take a note about when the vial was first opened. The rubber stopper should be cleaned with an alcohol swab. 

Draw air into the syringe. Draw back the plunger to fill the syringe with air up to the dose that you’ll be injecting. This is done because the vial is a vacuum and you need to add an equal amount of air to regulate the pressure. This also makes it easier to draw the medication into the syringe. Don’t worry; if you forget this step, you can still get the medication out of the vial.

Insert air into the vial. Remove the cap from the needle and push the needle through the rubber stopper at the top of the vial. Inject all of the air into the vial. Be careful to not touch the needle to keep it clean.

insert air

Withdraw medication. Turn the vial and syringe upside down so the needle points upward and pull back on the plunger to withdraw the correct amount of medication.

remove bubbles

Remove air bubbles. Tap the syringe to push any bubbles to the top and gently depress the plunger to push the air bubbles out.

remove bubles

6) Self-injection with a syringe:

Insert needle. Hold the needle like a dart and insert it into the muscle at a 90-degree angle. You should insert the needle in a quick, but controlled manner. Do not push the plunger in.

insert needles

Check for blood/blood vessel. Using the hand that is holding the skin at the injection site, pick up your index finger and thumb to stabilize the needle. Use your dominant hand (the one that did the injection) to pull back on the plunger slightly to look for blood in the syringe.

  • If you see blood going into the syringe, it means the tip of the needle is in a blood vessel. If this happens, withdraw the needle and begin again with a new needle, syringe with medication, and injection site. It’s rare to have this happen.
  • If you don’t see blood going into the syringe, the needle is in the correct place and you can inject the medicine.
check for blood

7) Inject medication. Push the plunger slowly to inject the medication into the muscle.

8) Remove needle. Withdraw the needle quickly and discard it into a puncture-resistant sharps container. Do not recap the needle. A sharps container is a red container that you can purchase at any pharmacy. It is used to collect medical waste, like needles and syringes. You should not put any of these materials into the regular garbage, as needles can be hazardous to anyone who handles the trash.

9) Apply pressure to the injection site. Use a piece of gauze to apply light pressure to the injection site. You can even massage the area to help the medicine be absorbed into the muscle. It is normal to see slight bleeding. Use a bandage if necessary.


Helpful Tips

Tips for an Easier Injection

To minimize possible discomfort before your injection:

  • Apply ice or an over-the-counter topical numbing cream to the injection site before cleaning it with the alcohol pad.
  • Allow the alcohol to dry completely before the injection. Otherwise, it might cause stinging.
  • Warm the vial of medication by rubbing it between your hands prior to drawing the medication into the syringe.
  • Have someone you trust give you the injection. Some people find it difficult to inject themselves.


What Are the Complications of Intramuscular Injections?

It is normal to experience some discomfort after an intramuscular injection. But certain symptoms may be a sign of a more serious complication. Call your doctor or health care provider right away if you experience:

  • severe pain at the injection site
  • tingling or numbness
  • redness, swelling or warmth at the injection site
  • drainage at the injection site
  • prolonged bleeding
  • signs of an allergic reaction, such as difficulty breathing or facial swelling

It is also normal to have some anxiety about performing or receiving an injection, especially an intramuscular injection due to the long needle. Read through the steps several times until you feel comfortable with the procedure, and take your time. Don’t hesitate to ask your provider or pharmacist to go through the procedure with you beforehand. They’re more than willing to help you understand how to perform a safe, proper injection.

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