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Side Effects of Statins

Overview

Statins are some of the most widely prescribed medications in the world. They’re commonly prescribed for people who have high levels of low-density lipoprotein (LDL), or “bad” cholesterol.

Statins can reduce your risk of cardiovascular disease and help prevent heart attack and stroke. If you already have cardiovascular disease, statins may help keep your condition from getting worse. Statins may also help increase your levels of healthy high-density lipoprotein (HDL), or “good” cholesterol, and improve the health of your arteries.

Most people who take statins have no noticeable adverse side effects. But side effects can happen, especially if you have certain risk factors. Many of these effects are the same for all statins. Some statins have unique side effects, as well. Here’s what to know.

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Side effects

Statin side effects

There are currently seven types of statins approved by the U.S. Food and Drug Administration (FDA). These include:

  • atorvastatin (Lipitor)
  • fluvastatin (Lescol)
  • lovastatin (Mevacor, Altoprev)
  • pitavastatin (Livalo)
  • pravastatin (Pravachol)
  • rosuvastatin (Crestor)
  • simvastatin (Zocor)

Common side effects of all statins

Side effects reported by some people include muscle pain and digestive problems.

Muscle pain is the most common side effect caused by statin use. A 2005 study found that over 10 percent of people taking high-dose statins had muscle pain.

Muscle pain can be uncomfortable. However, you should call your doctor right away if you have:

  • unusual muscle pain or cramps
  • tiredness
  • fever
  • dark urine
  • diarrhea

These could be symptoms of rhabdomyolysis, a dangerous muscle condition that can cause kidney problems.

For more information on what puts you at risk of these effects, as well as how they’re treated, read about why statins cause muscle pain.

Rare side effects of all statins

While taking statins, there is a small risk of:

  • memory loss or confusion
  • increased blood sugar, which can lead to diabetes
  • kidney or liver damage

Dark or bloody urine or pain in your upper abdomen or chest can be signs of serious kidney and liver disorders. If you have any of these symptoms while taking any statin, call your doctor right away.

Read more: Statins and the risk of diabetes »

Lovastatin

Lovastatin generally causes fewer side effects than other, stronger statins. The most common side effects of this drug include:

  • digestive discomfort
  • infection
  • muscle pain or weakness

Taking lovastatin with a meal can sometimes ease digestive trouble.

Simvastatin

When taken at high doses, simvastatin may be more likely to cause muscle pain than other statins. The more common side effects of taking higher doses of this drug also include:

  • dizziness
  • fast or irregular heartbeat

Pravastatin

People taking pravastatin have reported fewer muscle aches and other side effects. It’s generally well tolerated with long-time use. However, the following side effects can occur with this drug:

  • muscle stiffness
  • painful joints

Atorvastatin

The most common side effects of atorvastatin use include:

  • headache
  • stuffy or runny nose

Fluvastatin

Fluvastatin is an alternative for people who have had muscle pain when taking other, stronger statins. However, side effects of this drug are still possible. The most common side effects from fluvastatin use are:

  • diarrhea
  • infection, which can cause:
    • chills
    • fever
    • runny nose
    • sore throat
    • sweating
  • diarrhea
  • pain in joints
  • unusual tiredness or trouble sleeping
  • vomiting

Rosuvastatin

Rosuvastatin has the highest rates of reported side effects. Taking a lower dose may reduce or eliminate uncomfortable side effects. The most common side effects with rosuvastatin are:

  • headache
  • joint pain
  • pink or cloudy urine
  • rash
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Risk factors

What can put you at risk

Side effects are possible for anyone taking a drug. That said, certain factors can make it more likely that you’ll have side effects from taking a statin. You’re more likely to have side effects if you:

  • take more than one medication to reduce cholesterol
  • are female
  • have a small body frame
  • are 65 years or older
  • have kidney or liver disease
  • drink a lot of alcohol

Learn more: Types of cholesterol-lowering drugs »

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Takeaway

Talk to your doctor

Statin drugs can be valuable for controlling your LDL and preventing heart disease. However, side effects may be a concern, especially if you have effects that are painful or bothersome. If you have muscle pain or other side effects that you think are caused by taking a statin, talk to your doctor.

Don't suddenly stop taking your prescribed medication without talking to your doctor. If you have side effects from your drug, your doctor might adjust your dosage or recommend a different statin.

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