Hepatitis Viral Panel

Written by Corinna Underwood | Published on June 15, 2012
Medically Reviewed by George Krucik, MD

What Is a Hepatitis Viral Panel?

The hepatitis virus panel is an array of tests used to detect viral hepatitis infections. By using antibody and antigen tests, the viral panel can detect multiple kinds of virus simultaneously. It can also distinguish between current and past infections.

Antibodies are proteins made by your body’s immune system to fight against harmful substances. Antibodies react to proteins known as antigens. These proteins may be from fungi, bacteria, viruses, or parasites. Each antibody recognizes a specific type of antigen.

What the Test Addresses

Your doctor may recommend a hepatitis viral panel if you have symptoms of hepatitis such as:

  • abdominal pain or bloating
  • dark-colored urine
  • low-grade fever
  • jaundice
  • nausea and vomiting
  • weight loss
  • fatigue
  • breast development in males
  • general itching

The viral panel is used to:

  • detect current or past hepatitis infections
  • determine how contagious your hepatitis is
  • monitor your hepatitis treatment
  • check whether you have been vaccinated

The test may also be performed to detect:

  • chronic persistent hepatitis
  • delta agent (hepatitis D), a rare form of hepatitis that only occurs in people with hepatitis B (HBV)
  • nephrotic syndrome, a type of kidney damage

Where and How the Test Is Administered

Your doctor will need to take a sample of blood from your arm.

First, the site will be cleaned with a swab of rubbing alcohol. The needle will then be inserted into a vein. A tube will be attached to fill with blood. When enough blood has been drawn, the needle is removed. The site is covered with an absorbent pad.

If the blood sample is being taken from an infant or young child, your doctor will use a tool called a lancet. This pricks the skin and may be less frightening than a needle. The blood will be collected on a slide and a bandage will cover the site.

The blood sample will then be sent to a laboratory for analysis.

Understanding the Results

Normal Results

If your results are normal, you don’t have hepatitis and have never been infected with hepatitis or vaccinated.

Abnormal Results

If your blood sample tested positive for antibodies:

  • You have a hepatitis infection. It may be a recent infection or you may have had it a long time.
  • You have had a hepatitis infection in the past. However, you do not have it now and you are not contagious.
  • You have been vaccinated for hepatitis

Hepatitis A (HAV) test results:

  • IgM HAV antibodies meant that you have recently been infected with HAV
  • IgM and IgG HAV antibodies mean that you have had HAV in the past or been vaccinated for HAV. If both tests are positive, you have an active infection.

Hepatitis B test results:

  • HBV surface antigen means you are currently infected with HBV. This may be a new or chronic infection
  • Antibody to HBV core antigen means you have been infected with HBV. This is the first antibody to appear after infection.
  • Antibody to HBV surface antigen (HBsAg) means you have been vaccinated for or infected with hepatitis B.
  • HBV type e antigen means you have HBV and are currently contagious

Hepatitis C (HCV) test results:

  • Anti-HCV test means you have been infected with HCV or are currently infected.
  • HCV viral load means there is detectable HCV in your blood and you are contagious.

What Are the Risks of the Test?

As with any blood test, there are minimal risks. You may experience minor bruising at the needle site. In rare cases, the vein may become swollen after blood is drawn. This condition, known as phlebitis, can be treated with a warm compress several times each day.

Ongoing bleeding could be a problem if you have a bleeding disorder or are taking blood-thinning medication, such as warfarin (Coumadin) or aspirin.

Preparation for the Test

There are no special preparations necessary for this test. However, you should inform your doctor if you are taking any blood-thinning medications. Your doctor may advise you to stop taking certain medications.

What to Expect After the Test

Whether you are contagious depends on which virus you are infected with and how long you have been infected. It is possible to spread viral hepatitis even when you don’t have symptoms.

If you have been diagnosed with HAV, you are contagious from the beginning of your infection for up to two weeks.

If you have HBV or HCV, you will be contagious for as long as the virus is present in your blood.

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