Barrett’s Esophagus and Acid Reflux

Written by Robin Madell | Published on October 31, 2014
Medically Reviewed by Brenda B. Spriggs, MD, MPH, MBA on October 31, 2014

GERD and Barrett’s Esophagus

Acid reflux occurs when acid backs up from the stomach into the esophagus. This causes symptoms such as chest pain or heartburn, stomach pain, or a dry cough. Chronic acid reflux is known as gastroesophageal reflux disease (GERD).

Symptoms of GERD are often overlooked as minor. However, chronic inflammation in your esophagus can lead to complications. One of the most serious complications is Barrett’s esophagus.

What Causes Barrett’s Esophagus?

Barrett’s esophagus is thought to be the result of chronic inflammation. In some people with GERD, the acid irritates the esophagus so greatly that a change in the tissue lining the esophagus starts to take place. This change is called metaplasia. Metaplasia is a process when one type of cell is replaced with another. Esophageal cells are replaced with cells more like those seen in the intestines. 

No unique symptoms are associated with Barrett’s esophagus, but the symptoms of acid reflux can persist.

Who Gets Barrett’s Esophagus?

Barrett’s is usually found in people with GERD. However, according to the National Center for Biotechnology Information (NCBI), it only affects about 5 percent of reflux patients.

According to the Mayo Clinic, certain factors may put you at higher risk for Barrett’s esophagus. These include:

  • being male
  • having GERD for at least 10 years
  • being white
  • older age

Can You Develop Cancer from Barrett’s Esophagus?

Barrett’s esophagus increases the risk of esophageal cancer. However, this cancer is rare even in people with Barrett’s esophagus. According to the NCBI, statistics have shown that over a period of 10 years, only 10 out of 1,000 people with Barrett’s will develop cancer.

If you are diagnosed with Barrett’s esophagus, your doctor may want to watch for early signs of cancer. You will need regularly scheduled biopsies. Examinations will look for precancerous cells. The presence of precancerous cells is known as dysplasia.

Regular screening tests can detect cancer at an early stage. Early detection prolongs survival. Detecting and treating precancerous cells may even help prevent cancer.

Treatments for Barrett’s Esophagus

There are several treatment options for Barrett’s esophagus. Treatment depends on whether or not you have dysplasia.

Treatment for People with No or Low-Grade Dysplasia

If you don’t have dysplasia, you may just need surveillance. This is done with an endoscope. An endoscope is a thin, flexible tube with a camera and light.

Doctors will check your esophagus for dysplasia every year. After two negative tests, this can be extended to every three years.

You may also be treated for GERD. GERD treatment can help keep acid from further irritating your esophagus. Possible GERD treatment options include:

  • dietary changes
  • lifestyle modifications
  • medication
  • surgery

Treatment for People with High-Grade Dysplasia

Treatment is different with serious dysplasia. The goal is to remove the precancerous cells. This can be done in several ways. All methods carry a risk of serious side effects. Discuss the risks in detail with your physician before deciding on a treatment. Potential treatments include the following:

  • Endoscopic mucosal resection is performed using an endoscope. Damaged areas of the esophageal lining are cut away and removed.
  • Photodynamic therapy uses light to destroy precancerous cells. First the cells are sensitized with medication. Then they are exposed to light using an endoscope.
  • Cryotherapy uses an endoscope to freeze abnormal cells, resulting in cell death.
  • Radiofrequency ablation uses energy to destroy cells in your esophagus. A special balloon  inserted into your esophagus heats up and kills the abnormal cells.
  • Surgery can also be used to remove your esophagus. However, this can have particularly serious complications. It’s usually considered a last resort.

Preventing Barrett’s Esophagus

Diagnosis and treatment of GERD may help to prevent Barrett’s esophagus. It may also help keep the condition from progressing.

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