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Enzyme Markers

What are enzyme markers?

Enzymes are highly specialized complex proteins that aid chemical changes in every part of the body. For example, they help break down food so your body can use it effectively. They also help your blood clot. And they’re present in every organ and cell in your body. Enzymes are necessary for your body to function properly.

Enzyme markers are blood tests that analyze specific enzyme activity in the body. Some inherited diseases or conditions can cause these enzymes to stop working or be less efficient. Monitoring the rise or fall of enzyme levels can aid in the diagnosis of a variety of conditions.

Your doctor can order a blood test for enzyme markers, or a routine blood test to help uncover abnormalities. In some cases, you may need to take a test multiple times over the course of several days to measure changes over time.

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Types

What are the common types of enzyme markers?

CPK isoenzymes

The CPK isoenzymes test measures the creatine phosphokinase (CPK) in the blood. CPK enzymes are in the heart, brain, and skeletal muscles. Normal CPK levels vary by age, gender, and race.

Each laboratory may have minor differences in reference ranges, as well. In general, a CPK level of approximately 200 units per liter (U/L) or less is considered normal in an adult. This is the total CPK level in your body. More specific testing can be done, but this is not routine.

Read more: CPK isoenzymes test »

CPK-1 resides mostly in the brain and lungs. Increased levels of CPK-1 can be due to:

CPK-2 levels rise following a heart attack. Increased levels of CPK-2 may also be due to:

High CPK-3 levels can be a sign of muscle stress, a crush injury, or injury due to:

Heart enzymes

Some heart enzymes slowly enter your blood if you’ve had a heart attack and your heart is damaged as a result. A general test for emergency room patients with heart attack symptoms is a test for the presence of certain proteins in your blood. A doctor may check CPK-2, also known as CK-MB. This marker is highly specific for heart muscle injury and rises rapidly during a heart attack. Normal CK-MB should be between 5-25 international units per liter (UI/L).

The preferred marker of heart injury, though, is a protein called troponin. Troponin should generally be less than 0.02 nanograms per milliliter (ng/mL). The level takes longer to rise than CK-MB, but the protein stays in the bloodstream longer.

Learn more: Symptoms of a heart attack »

Liver enzymes

Elevated liver enzymes may be due to inflammation or damaged liver cells. Usually, elevated liver enzymes are related to an acute injury, or a process that occurred over a short period of time due to:

There are several markers that can be used to test liver function. These markers help separate whether or not the injury is to the liver parenchyma (liver cells) or to the biliary system. For the purposes of this article, the important tests are the liver aminotransferases: alanine aminotransferase (ALT) and aspartate aminotransferase (AST).

ALT is primarily produced by the liver, while AST can be from the liver, cardiac muscle, skeletal muscle, kidney, and brain. A normal ALT level is 29-33 IU/L for men, and 19-25 IU/L for women. A normal AST level may range from 10-40 IU/L for men and 9-32 IU/L for women.

These reference ranges vary from hospital to hospital. It’s important to compare your liver enzyme levels to the reference ranges provided by the lab.

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Procedure

How are enzyme marker tests performed?

The test is a routine blood test that takes place in a laboratory. No fasting or special preparation is necessary. But tell your doctor before the test about all prescription and OTC medications and supplements you take.

A blood test involves the following steps:

  • A healthcare provider will use an antiseptic to clean a small area of your arm, usually the inside of your elbow or the back of your hand.
  • They’ll then wrap an elastic band around your upper arm to create pressure and make it easier to access a vein.
  • They’ll insert a needle into your vein and blood will flow into a small vial. You’ll likely feel the stick of the needle or a stinging sensation.
  • After filling the vial, the healthcare provider will remove the elastic band and the needle.
  • They’ll place a bandage over the puncture site and send the blood sample to a lab for analysis.
  • The procedure should take only a few minutes.
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Risks

What are the risks associated with enzyme marker tests?

Your arm may be sore at the puncture site, and you might have some mild bruising or brief throbbing.

Most people have no serious or lasting side effects from a blood test. Rare complications include:

Contact your doctor immediately if you have any of these symptoms.

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Results

What do the test results mean?

Abnormal test results can indicate a variety of problems from disease to a simple muscle strain because enzymes are present in every cell of your body. Your doctor will be able to determine a proper course of treatment based on your exact enzyme marker levels and the symptoms you’re having.

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