Stribild

Written by Rachel Nall | Published on October 22, 2013
Medically Reviewed by George Krucik, MD, MBA on October 22, 2013

What Is Stribild?

Brand Name: Stribild
Generic Name: Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate, Quad

Stribild is one name for four medications: elvitegravir, emtricitabine, tenofovir disoproxil fumarate, and cobicistat. It is used to treat HIV. The U.S. Food and Drug Administration has approved Stribild for use by adults. A doctor prescribes these medications when a patient has not taken other HIV medication forms.

Read the FDA description of Stribild.

What Does Stribild Do?

Stribild is not a cure for HIV. But it does help reduce how quickly the HIV virus is able to multiply. Treatment with this medication results in an increase in the number of CD4+ immune system cells in the body. By boosting the immune system, Stribild helps a patient to be better able to fight off infection.  

This information is a summary. Before starting this medication, discuss questions with your healthcare provider and make sure you understand dosage instructions.

What Should I Tell My Doctor Before Starting Stribild?

Tell your doctor before taking Stribild if you:

  • are breastfeeding or planning on breastfeeding, as the HIV virus and Stribild can be transmitted to the baby
  • are pregnant or planning on becoming pregnant
  • have bone problems, such as osteoporosis
  • have kidney problems
  • have liver problems, such as hepatitis B or C.

Taking Stribild can worsen symptoms of liver disease. A doctor should always test patients for hepatitis B before prescribing Stribild.

What Medications May Interact with Stribild?

Always tell your physician about any prescription medications or herbal remedies you are taking.

Patients should not take Stribild with other HIV medicines. Medications that can adversely interact with Stribild include:

  • alpha-1-adrenoceptor antagonists, such as Alfuzosin
  • antimycobacterial medications, such as rifampin 
  • GI motility agents, including cisapride
  • dipivoxil (Hepsera), another HIV medication
  • HMG-CoA reductase inhibitors (statins), such as lovastatin (Mevacor), Lipitor, and Zocor
  • some herbal remedies, including St. John’s wort
  • neuroleptic medications, such as Pimozide
  • phosphodiesterase-5 (PDE5) inhibitors, such as sildenafil (Viagra)
  • sedative or hypnotic medications, including triazolam (Halcion)

Possible Side Effects of Stribild

There are severe and emergent side effects of these medications. Report to your medical provider immediately if you experience:

  • decrease in bone mineral density, which increases the likelihood you will experience a bone break
  • lactic acidosis or excess acid in the blood
  • signs of drug-induced liver disease (steatosis) that causes liver enlargement (signs include unexplained fatigue, light-colored bowel movements, a general feeling of being unwell, or pain in the right upper portion of the abdomen)
  • signs of renal or kidney impairment 

The following side effects may occur, but do not usually represent an emergency. Discuss with your doctor or healthcare professional if they continue or are bothersome.

  • changes in the distribution of body fat, such as an increasing amount of fat on the neck.
  • difficulty sleeping
  • fatigue
  • nausea or stomach upset

Taking Stribild with food can help to reduce stomach-upset symptoms.

This list may not describe all possible side effects. Call your doctor or healthcare provider for advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Stribild and Alcohol

Your liver is your body’s main method for filtering and breaking down Stribild. This is why Stribild can place excess demands on the liver. For this reason, you should avoid drinking alcohol when taking Stribild. Because your liver must filter alcohol as well, dinking alcohol may make Stribild less effective.

Where Should I Keep Stribild?

Stribild should be stored at room temperature room temperature or between 68 and 77 degrees Fahrenheit (20 to 25 degrees Celsius). Temperatures for storage can range from 59 to 86 degrees Fahrenheit (15 to 30 degrees Celsius). Always keep Stribild in its original container, with the container tightly closed. Do not use the medication if the seal over the Stribild bottle is broken or missing.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

FDA WARNING: LACTIC ACIDOSIS/SEVERE HEPATOMEGALY: LACTIC ACIDOSIS AND SEVERE HEPATOMEGALY W/ STEATOSIS, INCL. FATAL CASES, ASSOCIATED W/ NUCLEOSIDE ANALOGUE USE ALONE OR IN COMBINATION; SUSPEND TX IF CLINICAL OR LABORATORY FINDINGS SUGGEST LACTIC ACIDOSIS OR HEPATOTOXICITY.
NOT APPROVED FOR HBV INFECTION: SAFETY AND EFFICACY NOT ESTABLISHED IN HIV/HBV CO-INFECTION; SEVERE ACUTE HBV EXACERBATIONS IN HBV/HIV CO-INFECTED PTS WHEN D/C EMTRICITABINE OR TENOFOVIR; MONITOR HEPATIC FXN CLOSELY FOR AT LEAST SEVERAL MONTHS IN HBV/HIV CO-INFECTED PTS WHO D/C ELVITEGRAVIR/COBICISTAT/EMTRICITABINE/TENOFOVIR DISOPROXIL; INITIATE ANTI-HBV TX IF NEEDED.

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