- have an allergy to Retrovir or other medications
- are breastfeeding or planning on breastfeeding
- are pregnant or are thinking of becoming pregnant
- have any diseases related to muscles and muscle swelling
- have been diagnosed with alcoholism or have a history of alcohol abuse
- have been diagnosed with blood-related conditions, such as anemia or hemophilia
- have been diagnosed with liver or kidney disease
- doxorubicin (Doxil)
- hematologic, bone marrow suppressive, and/or cytotoxic agents, including ganciclovir (Zirgan, Vitrasert), interferon alfa (Multiferon), and ribavirin (Copegus, Rebetol, Vilona, Virazole)
- stavudine (Zerit)
- blood disorders, such as shortness of breath, headache, pale skin, chest pain, headache, or coldness in the hands or feet
- hepatotoxicity, such as hepatomegaly with steatosis, that affects your liver functioning; symptoms of this condition include dark urine, decrease in appetite, fatigue, jaundice or yellowing skin, nausea, and tenderness over the liver
- immune reconstitution syndrome, a condition that causes an inflammatory response in viruses in the blood, such as pneumonia or tuberculosis
- lactic acidosis, a condition that causes excess amounts of acid to build up in your blood; this causes symptoms such as weakness, tiredness, difficulty breathing, stomach pain, feeling cold, or feeling dizzy
- worsening of hepatitis B symptoms; a doctor should monitor a patient with hepatitis B and HIV for liver function closely
- changes in the distribution of body fat, such as an increasing amount of fat on the neck
- skin rashes
Brand Name: Retrovir
Generic Name: Zidovudine, AZT, ZDV, azidothymidine
The U.S. Food and Drug Administration has approved the medication Retrovir for the treatment of HIV. It can be used by adults and children over the age of four weeks. The medication is also FDA-approved to prevent mother-to-child transmission of HIV during pregnancy and birth. However, the medication does not guarantee that the virus will not be transmitted. When used as an HIV treatment, Retrovir is used in combination with other medications.
Read the FDA description of Retrovir.
Retrovir belongs to a class of medications known as nucleoside reverse transcriptase inhibitors (NRTIs). These medications block the effectiveness of an enzyme present in HIV known as reverse transcriptase. As a result, HIV cannot replicate as easily. Retrovir is not a cure for HIV.
Retrovir should be taken with food. The medication is also available in intravenous or IV preparation.
This information is a summary. Before starting this medication, discuss questions with your healthcare provider and make sure you understand dosage instructions.
Tell your doctor if you:
Always tell your physician about any prescription medications or herbal remedies you are taking.
Medications that can adversely interact with Retrovir include:
The following are severe and emergent side effects of Retrovir. Report to your medical provider immediately if you experience:
The following side effects may occur but do not usually represent an emergency. Discuss with your doctor or healthcare professional if they continue or are bothersome.
This list may not describe all possible side effects. Call your doctor or healthcare provider for advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The FDA has approved Retrovir for use during pregnancy to prevent mother-to-child transmission of HIV. An intravenous solution of Retrovir may be administered during the start of labor. The medication is also given to babies during the first six weeks of life to reduce the likelihood a baby will contract HIV from a mother who has HIV.
Retrovir should be stored at room temperature–somewhere between 59 and 77 degrees Fahrenheit (15 and 25 degrees Celsius). Intravenous Retrovir must be delivered at the same temperature within eight hours of starting the infusion. However, refrigerated intravenous Retrovir should be kept at 36 to 46 degrees Fahrenheit (2 to 8 degrees Celsius) and administered within 24 hours.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
FDA WARNING: Retrovir carries a black box warning because it can have life-threatening effects on the body, including lactic acidosis, liver conditions, blood disorders and/or muscle weakness known as myopathy. Seek immediate medical treatment if you experience symptoms of these medical conditions.
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.